Scion January 18, 2012 10:00 PM Or you could get off your bum and do actual exercise. While doing that you could eat less too. We already have a cure for obesity. What we need is a cure for pathological foolishness. Tysto January 18, 2012 11:53 PM \"However, there is still a long way to go before the hormone is made into an actual drug.\"Drug?! I want it made into candy! RonLee January 19, 2012 02:38 PM I know that obesity is a problem now, and there are many supposed remedies - drugs, diets, TV exercise gadgets, etc - out there, but. Scion is right: ultimately the solution is a body in motion burning more calories than it takes in! All that said, could Gizmag have chosen a more cringe inducing picture for the article??? Argh!!! ADVENTUREMUFFINffin January 19, 2012 06:05 PM In Euripides\' play Heracles, Iris appears alongside Madness, cursing Heracles with the fit of madness in which he kills his three sons and his wife Megara.Thus an appropriately named drug. Science, in its reductionist ways, does not see the dangers it creates alongside of a replacement to exercise, sensible eating. Brian Brehart January 19, 2012 06:51 PM Both Scion and RonLee show their ignorance when it comes to obesity. To them, the solution is simple: just get out and exercise. But for many it\'s not that simple. For many, even exercising one hour a day, every day will do little if nothing. A potential drug like this is geared toward those who are genetically behind the eight ball when it comes to weight loss. As a matter of fact, all \"extreme\" versions of weight loss (liposuction, banding, stapling, etc.) are not designed for the lazy, but for the genetically unfortunate. And for the rest of us, sometimes it\'s simply not feasible to get in any sort of exercise. I personally know people who have a 3-hour round-trip commute to work, plus they work from home and spend time with their families, which leaves very little time for them to exercise. Should they just quit their jobs? Ignore their families? Let their homes fall to ruin? Something\'s gotta give, and for many of us, exercise is the easiest to drop and the one we\'ll miss the least. EinSascha January 19, 2012 08:04 PM \"Or you could get off your bum and do actual exercise. While doing that you could eat less too.\"Well, I thought the same until I started to put up 20 kg without change in lifestyle, no matter how much I exercised and what diet I tried (e.g wholefood, high-protein, low-fat, low-carb, vegetarian). Of course, I could settle for a 1500kcal/day diet. Which by the way gives not only constant hunger, headaches and an overall feeling of having a flu. It also reduces my IQ which is unfortunate, if you\'re a software designer. And as soon as I stop, weight goes up again.The situation for me seems to be like this: I\'m somehow fixed at my weight, I can only transfer kilos from fat to muscles (or back).On the other hand, there are people that don\'t do sport, eat everything the doctor warns you about and stay skinny. Maybe some fat guys just want the same chance even though their genes think different. Dawar Saify January 19, 2012 09:52 PM Obesity is multi factoral, obesity drugs, cholesterol reducing drugs have been a blessing to many, and they have few side effects. At the same time, everyone should do regular exercise. Snake Oil Baron January 19, 2012 10:55 PM Fat people are sinners; SINNERS!!! You just need to look at the grinning abomination, illustrating the article, scoffing pills with contempt for temperance, forbearance and God\'s devine law to see that!!! And as one such sinner myself I personally will not risk being unfairly tolerated by decent, God-fearing folk just to shed a few pounds and live a few extra years. RAFAEL SCHLOSER January 20, 2012 02:09 AM SOUNDS AS IF THE HOLY GRAIL HAS BEEN DISCOVERED.....HALELUYAH Grunchy January 20, 2012 02:34 AM I\'m into week 8 of a 10 week workout program (TSC transformation super challenge) and let me tell you, exercise is painful. I\'m surprised to discover that at less than 10 weeks I still won\'t have accumulated any measurable amount of Irisin. I have lost several inches, but not much weight. The biggest effect I\'ve found so far is that (1) I ache all over all the time and (2) I have surprisingly better muscle tone and much more strength than I\'ve ever had. I must have lost a lot of fat but it\'ll take me another 10 weeks at least to get rid of my midriff fat to show off any abs. The point about lack of time really hits home, it takes me about an hour to do a 20 minute workout when you factor in psyching up; doing it; cooling down; and clean-up shower afterwards. I imagine this pill, if and when it ever materializes, will only be available by prescription and only for people who are really in trouble, because I can easily see it being abused to no end. One thing the pill will never be able to do is get you that crucial conditioning. For instance, at the pharmacy a few days ago I tried out the blood pressure machine and was astonished to find my pulse rate is now down to 47 beats per minute. In the past it was always 80 bpm or higher. The benefits of exercise is truly shocking, but so too are the body pains and aches and of course I cannot stomach those ice baths they recommend.