Nairda February 4, 2014 01:14 AM Good. Inject a mild acid into a cancerous tumor then zap it. After the body has re-metabolized some of the converted cells repeat the process until the tumor is all gone. Jay Gatto February 4, 2014 12:05 PM What happens when cells are subject to metabolic acidosis, and stressed with heat, cold, or a mechanical stimulus, such as ultrasound? StWils February 4, 2014 01:42 PM This would be a good occasion to revisit the work of an engineer who tried to work out an application of RFI to kill cancer. He was strongly motivated by the progressing cancer that did eventually kill him but nonetheless, his attempts showed great promise. This may well be a very useful tool to combine with other tools that independently are an incomplete therapy. DomainRider February 4, 2014 02:43 PM It will be interesting to see if they can get such an embryo to term and then grow into a healthy adult. The concern with these stem cell reversions is that they remain stable in their new differentiated form and are not more liable to become tumours. sidmehta February 4, 2014 03:31 PM Who would have thought it was as simple as putting cells in acid or heating / cooling them? OTOH Sounds too obvious to be true. kamaaina February 4, 2014 04:17 PM As is always the case with a major break through, Dr. Vacanti might have paved the way, but the idea of soaking in acid came from Dr. Obokata. There is no doubt it is a joint collaboration, but he should not try to take the main credit when it belongs to her.Her first article was rejected by Nature by a reviewing scientist with reknowned credential to be too simplistic to the point of ridiculing the existing, extremely costly and intricate processes other researchers have been engaging in. If this can be replicated with human cells, it will make the pluripotent cells so inexpensive, the researchers who were after gold mines may be disappointed. Willsonx February 4, 2014 11:55 PM Very impressive breakthrough indeed. In error though is the quote: "the harvesting of ESCs has its opposition, as it involves the destruction of human embryos" Dr. Robert Lanza MD has produced ESC lines from embryos without any destruction and is indeed using them routinely for human regenerative procedures. These true ESC's, I suggest, will be much more active and functionally focused than converted adult cells. vblancer February 5, 2014 04:03 AM For those of us with spinal and spinal cord and nerve damage any of these stem cell breakthroughs are hope. Even if it does not happen soon enough to help me it would be great if my daughter did not have to suffer all her life like I have since 1973. Since a night in the Winter in early 1973 I have been in pain every minute of every day and after three episodes of "broken backs" resulting in 8 compressed verts and one burst fracture and all that goes with it stem cells are our best hope.My problem stems from osteoporosis and a much too adventuresome life style. It was only in my late forties we found I was in the lowest 1% of men my age for bone density and by then most of the damage was done. Now it is trying not to fall and things like drugs to help with the bone density but the only hope for the pain is a combination of pain meds.Three different orthopedic surgeons, very good ones, have told me they are amazed I still walk. Still if there could be a way to help it would be great. Last night NPTV Universe with Stephen Hawking had a show on the same general subject of stem cells and at the end he lamented that it is too late for him. I am 10-12 years younger but it is probably too late for me too but if they want to try some out I would be first in line. Brian Hall February 5, 2014 02:56 PM Mechanical stress or shock is a common event in the life of many cells; it must take rather more than that to stimulate pluripotency. Unless that's a regular stage in tissue repair. JP February 5, 2014 04:31 PM The real issue(s) surrounding stem cells is: money! Will people with neuro issues- such as sci (since 1961)- really be allowed to utilize functional improvement/pain/etc. Treatment from stem cells, or will health insurance and big pharma weild the real power and keep it on the shelf?!Folks need to "rise up" and demand immediate usage right now!, as we have been "g pigs" for years for drugs, etc.Researchers know that the stem cells work, or the little hope on dr. Hawkings' stem cells program on the science channel would have been put off.Way too many of us are not in the 'miracle cure' mode, but functional improvement is a whole solid ball of wax that needs to come out now!