Cells
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Right now, drug developers have high hopes on Polo-like kinase 1 (PLK1) inhibitors for treating advanced cancers. But a team of scientists has found it also shows huge promise in calming inflammation, and could be used to treat gout and heart failure.
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Researchers have, for the first time, observed a mechanism used by cancer cells to resist the effects of chemotherapy. The findings could be used to develop targeted drugs to help override it and make chemotherapy more effective.
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Swedish scientists have demonstrated a new potential way to manage diabetes, one of the most pressing health problems of our time. It turns out the eye might be a useful place to implant insulin-producing cells to control blood sugar levels.
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Researchers have converted brain immune cells into neurons, replacing damaged ones and restoring function to stroke-affected mice. If the same results can be achieved in human cells, it opens the door to a potential treatment for stroke.
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Following on from the discovery of programmable DNA-cutting enzymes Fanzors, scientists have identified more than 3,600 Fanzors in a broad set of species. It presents a massive opportunity in the development of new medicines, gene therapy and biotech.
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Researchers have combined two microscopic imaging techniques in one microscope, providing scientists with a high-resolution method of tracking single molecules in a cellular context, letting them visualize, in minute detail, what’s happening inside cells.
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Researchers have found that remnants left over after a cell divides contain RNA that, when taken up by other cells, can spread cancer’s genetic blueprint. The finding opens the door to harnessing this mechanism as a way of treating cancer.
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Senolytics, a new class of drugs that counter, or reverse, age-related health conditions, is a field of medical science swiftly gaining momentum. The latest, which uses molecular auto-assembly to destroy problematic senescent cells, shows great promise.
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Researchers have found that millions worldwide carry a gene variant that controls ‘explosive’ cell death and is linked to inflammation. They say it may explain why some people are prone to developing inflammatory diseases.
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Finding the molecular key to turn fat tissue from white to brown has huge potential for weight loss, yet the cellular code has been a hard one to crack. Scientists are now one step closer, finding a way in to manipulate the tricky white fat cells.
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The 2023 Nobel Prize in Physiology or Medicine has been awarded to biochemist Katalin Karikó and immunologist Drew Weissman for discoveries that enabled the development of mRNA vaccines against COVID-19.
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In a major step towards creating new organs on demand to alleviate donor waitlists, Stanford scientists have now received a contract and funding for experiments to 3D print human hearts and implant them into live pigs.
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