Immunotherapy
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Scientists have reported that five patients undergoing an experimental treatment for lupus have all entered remission for up to 17 months. The promising breakthrough came from the use of CAR T cell immunotherapy, increasingly used to treat cancer.
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Scientists at the University of California San Francisco have found a way to fight one of the most common cancer-causing mutations. The new drug puts up an “eat me” marker that can help the immune system or other drugs find and kill the cancer.
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During long-term battles with cancer or infection, immune cells can become exhausted. Now, researchers have identified a specific molecule that helps certain T cells refresh themselves, which could unlock more effective immunotherapy.
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By using advanced screening methods to tune into the communications taking place between individual cells, scientists have produced a full connectivity map of the human immune system, which may help develop new treatments for disease.
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Scientists have developed a new light-activated “photoimmunotherapy” that could help treat brain cancer. The key is a compound that glows under light to guide surgeons to the tumor, while near-infrared light activates a cancer-killing mechanism.
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Researchers have found that adding a booster protein can significantly improve the outcome of cancer immunotherapy. Tests in mice showed the protein produced 10,000 times more cancer-targeting immune cells, with all mice surviving the experiment.
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A newly developed technology makes use of microbubbles and ultrasound to deliver immunotherapy drugs with great potency, significantly reducing primary and metastatic tumor growth in mouse models of breast cancer.
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Type 1 diabetes can be a rare but serious side effect of a cancer treatment that use what are known as immune checkpoint inhibitors. In a new study in mice, researchers in Japan have shown that administering stem cell therapy could help prevent this.
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Pancreatic cancer is one of the most deadly forms of the disease, resistant to many treatments. Now, scientists have identified how the tumors protect themselves so well – and more importantly, found a way to potentially bust through those defenses.
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University of Michigan researchers have been exploring how ultrasound can combine with the body's immune defenses to take out tumors through a one-two punch, with a new study on rodents returning some highly promising results.
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Stanford University scientists have taken aim at a key problem holding back an exciting form of cancer immunotherapy, and demonstrated how a novel gel can help overcome it by acting as an injectable holding pen for killer immune cells.
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Preliminary data has provided promising signs for a new cancer treatment that combines immunotherapy with an mRNA vaccine. First reports from the Phase 1 human trial indicate the treatment is safe and potentially effective against solid tumors.
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