Inflammatory
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A new drug for severe influenza successfully keeps patients at the perfect level of lung inflammation to protect against lung damage while still allowing the immune system to fight off the infection. It's effective in mice even days after infection.
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As common as asthma is, exactly how it starts remains murky. Scientists have now identified a new root cause, and importantly a new angle for treating the disease that can prevent the main symptoms.
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Giving infliximab, an immunotherapy drug, as soon as possible after diagnosis with Crohn’s disease significantly reduced complications, including the need for urgent surgery by a factor of 10, a clinical study has found.
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Ever since SARS-CoV-2 emerged, the virus has been known for its novel effects on the brain. But exactly how is it causing these symptoms? A new study suggests that the answer lies in the way our vagus nerve talks to the brain.
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Researchers have developed drug-loaded nanoparticles that target the cells that cause damaging inflammation following a spinal cord injury. The novel nanotherapy opens the door to new therapeutic possibilities for people with spinal injuries.
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A drug currently used as a second- or third-line treatment for those with rheumatoid arthritis has shown huge promise as a preventative, stopping the onset of the debilitating and painful disease in 92.8% of at-risk participants after 12 months.
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In yet another surprise attribute of the new class of obesity drugs, scientists have found that GLP-1 receptor agonists can also subdue brain inflammation, giving them a potential ‘superpower’ in the fight against Alzheimer’s and Parkinson’s diseases.
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Researchers have worked with biology rather than against it, fitting microparticle 'backpacks' to important inflammatory cells called macrophages to significantly reduce lesion size and inflammation caused by traumatic brain injury.
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Researchers have developed a novel anti-inflammatory from a Southeast Asian medicinal plant that doesn’t suppress the immune system like currently used corticosteroids do, opening the door to a new class of anti-inflammatory drugs.
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Restoring damaged nerves caused by multiple sclerosis could be within reach, thanks to a breakthrough in small molecule drug research. Scientists say their new compound has a "stunning effect on rescuing myelin," which would be pivotal in reversing MS.
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Researchers found that 92% of severe asthmatics could decrease their daily steroid dose after receiving biologic therapy to reduce lung inflammation, minimizing the risk of adverse effects associated with long-term steroid use.
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Research has revealed how genetic changes in a specialized population of brain cells called microglia contribute to neuroinflammation and, in turn, to Alzheimer’s disease. The findings could lead to more effective, targeted therapeutics.
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