Alzheimer's Disease

A Colombian man's novel genetic mutation that stalled the symptoms of his rare form of Alzheimer's for 20 years has been identified. The discovery could lead to therapies that boost people’s resilience against the debilitating disease.

A new study has identified a subset of microglia, the brain's immune cells, and their important role in brain development and cognition that could pave the way for new treatments for neurodegenerative conditions like Alzheimer’s disease.

Using AI, researchers have created the first map of a protein group known as the Commander complex, which functions as a "postal worker" in the body. The new understanding opens the door to new drugs and modalities for fighting a range of conditions.

Conventional tests for Alzheimer’s disease don't provide information about what stage it's at. Now, viewing pathological protein clumps with atomic-force microscopy may help doctors not just detect the disease but determine how far it has progressed.

A Phase 3 clinical trial of the drug donanemab has shown it can significantly slow cognitive and functional decline in people with early-stage Alzheimer’s disease, compared with existing treatments.

It is believed that long before Alzheimer's or Parkinson's diseases present obvious symptoms, the disorders may be noticeable in changes to a person's sleep patterns. A new project aims to see if such changes can be detected by an earbud-like device.

A common sleeping pill showed promise in combating the substances that lead to the harmful tangles and plaques in the brain that contribute to Alzheimer's disease, but larger, more comprehensive studies are needed to confirm the results.

We've long known of a link between exercise and benefits to the brain, but there's a lot of mystery as to the precise processes involved. Scientists have unlocked another piece of the puzzle, showing how muscle cells fire up important neural pathways.

In new research, the presence of a blood-based sugar molecule helped predict the onset of Alzheimer's up to a decade before symptoms appeared. The protocol could join others in spotting the condition early and slowing its progression.

Evidence has been mounting that high blood pressure can clear a path to dementia. Now, for the first time, researchers have identified the nine areas of the brain that show how, opening the door to potentially preventing related cognitive decline.

Dementia is a debilitating disease that affects millions of people worldwide. With no available cure, the focus has shifted to prevention. A study has provided new evidence about the link between magnesium intake and brain health.

Scientists have identified 238 genes involved in Alzheimer's disease, and one in particular piqued their interest. They believe the Surf4 gene's role in keeping messaging pathways open offers new clues as to how this devastating disease takes hold.