Antibiotic

Bacteria are great at resisting antibiotics, but they can’t fight tiny drills ripping them open. Researchers have now demonstrated next-generation molecular drills that are activated by blue light and could revolutionize the fight against superbugs.

Algorithms have helped uncover a new antibiotic that shows promise against some nasty bacteria, using a novel mode of attack that should be hard for them to develop resistance to. Most importantly it could unlock a whole new arsenal of antibiotics.

New studies have highlighted the importance of judicious antibiotic use, one found antibiotics can increase a person’s risk of fungal infections, while another suggests antibiotic use in old age is linked to higher risk of inflammatory bowel disease.

A study has shown how engineered bacteria can protect the gut microbiome from the impact of antibiotic use. Mouse studies showed the bacteria breaks down antibiotics in the intestine while still allowing high levels of the drugs to enter the bloodstream.

While it's a good idea to avoid the overuse of antibiotics whenever possible, little else works on severe cases of acne. There may be new hope, however, as recent research suggests that probiotic bacteria could provide an effective treatment.

Failing antibiotics could lead to a future “dark age of medicine” where once-simple infections become lethal again. Scientists have now found a way to restore antibiotics to their former strength, by repurposing a drug developed to treat Alzheimer’s.

Scientists are reporting successful preclinical tests of a nasal spray designed to prevent the neurodegeneration associated with dementia. The spray combines two cheap drugs and was found to improve cognitive function in several mouse models of dementia.

Modern medicine is locked in an arms race against antibiotic-resistant “superbugs.” A new treatment may give us the upper hand again by knocking out enzymes that bacteria use to defend themselves against the drugs.

Antibiotics were one of the most important inventions of the 20th century, but bacteria are developing resistance to them. Now researchers have shown that ultrashort pulses of laser light can kill bacteria and viruses, without harming human cells.

Pneumonia is usually treated with antibiotics, but bacteria are developing resistance to them. Now, NIH researchers have found a way to boost immune cells to eat the bacteria more effectively, potentially leading to a new pneumonia treatment.

Scientists may have found a way to re-enlist old antibiotics in the fight against superbugs. Gold nanoparticles were wrapped in molecules that seek out bacteria and disrupt their cell membranes, allowing existing drugs to kill them easier.

Antibiotic-resistant bacteria are poised to become a major health threat in the coming decades – but new antibiotics may have been inside us all along. A search algorithm has discovered dozens of potential antimicrobial peptides in the human body.