Fat cells
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A new article has proposed a novel hypothesis for the cause of Alzheimer’s, arguing the disease is caused by a damaged blood-brain barrier allowing fatty molecules to invade the brain and trigger a cascade of events resulting in cognitive decline.
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Harvard scientists studying the molecular structure of cells under obesity-related stress have spotted alterations in the architecture that can be patched up, with "striking" results that restore them to healthy metabolic function.
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Scientists have found that modifying so-called "checkpoint proteins" in the immune system can regulate inflammation in fat tissue, with the result being significant reductions in obesity and diabetes in pre-clinical models.
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Better understanding the relationship between obesity and complications like type 2 diabetes can offer new ways to prevent adverse health effects faced by obese subjects, and a new study has found a new target likened to an "energy crisis" in fat cells.
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Scientists at the Norwegian University of Science and Technology have found that chemicals in plastic could be helping drive rising rates of obesity around the world, by entering the human body and interfering with our metabolism.
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Next-generation therapies that fight obesity could come in many forms, but one example from Nanyang Technological University that uses a unique combination of light and metabolic function to break down fat has some unique advantages.
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A new study has shown how targeting an enzyme within fat cells can alter sensitivity to leptin – a hormone that plays a key role in appetite regulation – and in turn drive rapid weight loss in obese mice, while also improving overall metabolic health.
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A new study has shed light on a molecular process underpinning impaired metabolism and endurance in skeletal muscle associated with obesity, and reveals how a growth factor found in a South American plant can alleviate these deleterious effects.
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Recent studies have shown how the compound celastrol can tackle obesity in mice, but with harmful side effects. A new understanding of how the compound works on a cellular level could allow these effects to be avoided.
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A new study has revealed a novel signaling pathway through which bad fats are converted into healthier forms, opening up a new possibilities around weight loss and the improvement of metabolic health.
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The hormone leptin is central to the way our bodies regulate appetite. A new study has revealed some of the molecular machinery behind its functioning, and shown how the loss of a key protein can drive insatiable appetites and obesity in mice.
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A drug originally designed to treat Alzheimer’s has been found to reduce obesity and improve heart function in mice. The drug was previously found to be ineffective treating dementia, but it's suggested it could be useful in stimulating fat metabolism.
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