Spinal

A drug under investigation as a cancer treatment has shown exciting promise in a rather different branch of medical research, with scientists demonstrating how it can promote nerve repair following spinal injury.

Human trials have shown that hydrogel injections are a promising, effective treatment for chronic lower back pain caused by degenerative disc disease (DDD). The treatment is far less invasive than other surgeries, and has been given FDA approval.

In what is being described as a world-first, scientists in Israel have reportedly grown spinal cord implants utilizing tissue extracted from human volunteers. Those implants were then used to restore walking abilities to previously paralyzed mice.

As people get older, the intervertebral discs in their spine tend to deteriorate, some of which end up being surgically replaced with implants. A new patient-specific spinal model, however, could help determine how successful such surgery will be.

A new type of artificial scaffold encourages regenerating neurons to grow towards one another and bridge busted connections more efficiently, offering new hope for healing damaged spinal cords and restoring communication links between the brain and body.

Spinal cord injuries are among the most debilitating. In a new breakthrough study, Northwestern University researchers have developed a gel containing “dancing molecules” that allowed paralyzed mice to walk again four weeks after a single injection.

Scientists have shown how so-called senolytic drugs that remove destructive senescent cells can prevent age-related deterioration of spinal discs, raising the prospect of a new opioid-free treatment for back pain in humans.

By targeting the same mechanisms through which epidural anesthesia controls pain during child birth, engineers at the University of Cambridge have demonstrated a new medical implant that could offer relief from other types of severe pain.

Unfortunately there isn’t much that doctors can do to repair the damage after a spinal cord injury. But UCLA researchers have shown in tests in mice that injections of a porous scaffold material can help the body patch up the damage.

An analysis of 13 case histories has found intravenous injections of stem cells lead to motor function improvements in patients with spinal cord injury. The research claims the therapy is safe but clinical trials are needed to further affirm efficacy.

German scientists have restored the ability to walk in mice that had been paralyzed by a complete spinal cord injury. The team created a “designer” signaling protein and injected it into the animals’ brains, stimulating nerve cells to regenerate.

The authors of a new study have found that spinal cord stimulation can not only reduce pain in Parkinson's subjects where other treatments have failed, but also improved motor symptoms in almost three quarters of the patients tested.