Drug

HIV can currently be managed with a lifelong daily drug regimen, but unfortunately the infection can’t be eliminated entirely. Now researchers may have found a way to trip a cellular “alarm” to alert the immune system to clear out infected cells.

Stanford scientists have developed a new hydrogel with a Velcro-like molecular structure, letting it last longer at body temperature. The hope is that it could be injected into a patient to deliver drugs over weeks or months as it slowly dissolves.

One common symptom of multiple sclerosis (MS) is vision impairment, and it can progress to blindness in some cases. Now, researchers at the University of California, Riverside report a drug that was able to reverse that vision loss in mice.

Bacteria are fast evolving resistance to antibiotics, meaning our best drugs could soon stop working entirely. Now researchers have found a way to bypass drug resistance in these so-called superbugs – by distracting them with predatory viruses.

Killing cancer cells isn’t too hard – the tricky part is doing so without harming healthy cells. Now researchers have developed nanoparticles that selectively release drugs inside tumors, while keeping them safely locked away when in healthy cells.

Cancer cells are very energy-hungry, which could be a potential weakness. Now, researchers have developed an experimental drug that blocks mitochondrial metabolism, starving cancer cells of energy while leaving healthy cells relatively unscathed.

The influenza virus has proven a very tricky foe to fight. Now, researchers at EPFL have developed synthetic molecules that can kill the flu virus by mimicking human cells, and putting the squeeze on the virus when it attaches itself to the decoy.

EPFL scientists have demonstrated a new method to make immunotherapy more effective and directed against cancer. The team designed microparticles containing drugs that are only released when T cells physically squeeze them, on contact with cancer.

Researchers have developed a drug that can mimic inflammation signals to lure stem cells to damaged tissue, without causing any further inflammation. The technique could be a boon for regenerative medicine to treat neurological disorders.

VEEV is a mosquito-borne virus that, in the worst case scenario, can infect the brain and become deadly. Now scientists have discovered the protein it latches onto – and used it to create a decoy molecule that draws the virus away from the brain.

A phase 2 clinical trial of a cholesterol-reducing drug called evinacumab has reported promising results. In patients with extremely high cholesterol, the drug was able to reduce levels by about half, compared to a placebo.

The growing problem of antibiotic resistance isn’t slowing down, which could soon render our best drugs useless against infection. Now, an existing rheumatoid arthritis drug could be repurposed to cancel bacteria’s resistance to antibiotics.