According to the World Health Organization, there were approximately 207 million cases of malaria worldwide in 2012, 627,000 of which proved fatal. Unfortunately, the disease most often occurs in developing nations, where diagnostic equipment may not be available. This means that doctors can't determine the particular strain of malaria from which a patient is suffering, and thus don't know which medication will work best. Manu Prakash, an assistant professor of bioengineering at the Stanford School of Medicine, hopes to change that ... using his disposable folding paper microscope.
Known as the Foldscope, the device can be assembled on site by the user in just a few minutes, from flat-packed components. It's made almost entirely of cardstock paper, with the exception of its poppy seed-sized spherical lens. The lenses are in fact actually a type of abrasive grit, used to round off the rough edges of metal parts.
Materials-wise, each microscope is worth about 50 cents. Using them is fairly simple – as Stanford describes it:
"A sample is mounted on a microscope slide and wedged between the paper layers of the microscope. With a thumb and forefinger grasping each end of the layered paper strip, a user holds the micro-lens close enough to one eye that eyebrows touch the paper. Focusing and locating a target object are achieved by flexing and sliding the paper platform with the thumb and fingers. Because of the unique optical physics of a spherical lens held close to the eye, samples can be magnified up to 2,000 times."
Additionally, stains can be added to samples to detect specific organisms, plus a watch battery-powered LED can be added to project images onto a wall.
Not only is the Foldscope dirt cheap and user-friendly, but it's also very rugged, and can simply be incinerated (along with the biological sample in it) after one use. Along with its use in diagnosing blood-borne diseases such as malaria, Prakash hopes that it could also be utilized in educational programs, to inspire children to become scientists.
The Foldscope can be seen in use in the video below.
Source: Stanford University
This could be used for educational purposes, in middle and high school's all over the country, on field trips they are cheap enough every child could have their own, if they were dropped on the ground and were lost they will biodegrade. By the looks of it they had developed a water proof version in the video, probably with very little added cost, so these could also be used underwater in micro-marine biological research. I really like microscopes despite not owning one yet myself, and i absolutely love the direction this field is going, pretty soon we will have extremely high powered microscopes that are small that we can just attach to our smartphones and it will be accessible to all, and i really hope that starts to inspire more people about science and to take up more scientific endevours, we need more people working to understand scientific things if we are going to better our world.
As they can be produced so cheaply and given that in many developing countries people have to exist on less than $1 a day, it would be good if they could be given them absolutely free. So why not sell them here at a small profit and distribute them free to medics in poor countries? [e.g. you buy one here and we send one free to a developing country]
I can imagine most parents in the rich world would pay two or three dollars to buy one for their children and the profit could fund the free ones.
Seriously, though, kudos to the designers!
In the video presentation you said something about scalability of doing a billion tests for malaria and it made me recall an article which I had read about recently regarding oscillating magnetic fields by Henry Lai, UW research professor of bioengineering,who found the malaria parasite Plasmodium appears to lose vigor and can die when exposed to oscillating magnetic fields, which Lai thinks may cause tiny iron-containing particles inside the parasite to move in ways that damage the organism.This was in the year 2000.
Here is a link: http://www.washington.edu/news/2000/03/30/magnetic-fields-may-hold-key-to-malaria-treatment-uw-researchers-find/
Professor Lai did not follow it up since as far as I know but in 2011 the experiment to confirm this by Dr Robert Brown and others was done on malaria and the research paper is attached.
Or look up malaria oscillating magnetic fields in google.
Now just imagine that instead of people going to get various injections or tablets which may or may not work all they had to was walk in and sit in a room between 2 helmholtz coils for an hour and then walk out with the malaria parasite severely weakened.
The oscillating magnetic field does not have to be very powerful at all.It could be powered by the mains,a car battery or solar cells.
The device would not be expensive just a frame with the 2 helmholtz coils a cheap oscillator to drive the alternating current into the coils and a power supply.Of course it could be scaled up into a room to treat many people at the same time.They don't have to do anything.Just sit between the 2 helmholtz coils.
Helmholtz coils are nothing special or expensive and just consist of copper coils in a flat pancake disc or flat rectangular shape (see google images) .They are routinely used in cathode ray tubes for tvs,oscilloscopes,etc to steer the electron beam.
I urge you to please read the attached research paper.It has all the details of the experiments and all the facts and figures and possible mechanism of action.
I myself had to read it a few times but it is definitely worth it and you with your resources and contacts would not just make a difference with the Foldscope to test the blood for malaria but also to treat it too with the above simple device.
Yours Sincerely,
S Callum.
Introducing rabbits because you like shooting them and accidentally spread species is entirely different from a biologist finding a substitute to fill the niche for malaria mosquitoes.