Pain Relief

Scottish woman Jo Cameron is a medical marvel who feels little pain, fear or anxiety, and had faster wound healing, thanks to a specific gene mutation. Now, scientists have studied why in more detail, in the hopes of unlocking future drug targets.

Early preclinical work led by researchers from Harvard has found elements in a toxin produced by the anthrax bacterium can silence activity in pain-signaling brain neurons. The research raises the prospect of a new model for future pain therapeutics.

A new consensus statement is calling for the common painkiller acetaminophen (aka paracetamol) to be used cautiously during pregnancy, saying there are potential neurological and reproductive issues in children associated with excessive use of the drug.

A new proof-of-concept study suggests CRISPR gene therapy may be a promising alternative to opioids for chronic pain. The preliminary investigation demonstrated lowered pain sensitivity in mice after temporarily repressing activity of a specific gene.

New research led by scientists from UT Southwestern suggests a novel combination of three old antibiotics may be repurposed into an alternative to opiates for a particular kind of nerve pain.

Spider venom isn’t normally something you want in your body, but there might be exceptions. Australian researchers have identified two peptides from tarantula venom that show promise in blocking organ pain, working particularly well in mice with IBS.

New research is presenting evidence that cannabis can significantly reduce the severity of headaches and migraines. But the question remains: why are scientists coming up with such discordant results on whether cannabis can reduce pain?

Australian researchers have discovered a fungus in Tasmania that produces novel molecules with similar activity to opioids. These never-before-seen molecules may have similar analgesic properties to morphine but without its dangerous side effects.

By studying the way pain works in injured fruit flies, scientists have for the first time uncovered evidence that its effects can be long-lasting, something they say opens up new opportunities for more effective treatments for chronic pain in humans.

A new study has developed a novel method to tame one of the world’s most potent toxins, tetrodotoxin, commonly found in the pufferfish. The research demonstrates a way to control the spread of the toxin and harness it into a local anesthetic that can numb targeted regions for up to three days.

Mole-rats are pretty amazing animals, with a remarkable resistance to pain. A new study has uncovered the molecular reasons for the pain insensitivity, which could eventually lead to new pain relief techniques for human use.

A woman in Scotland has been found to have a previously-unknown genetic mutation that makes her almost completely immune to pain. Her wounds heal faster and she seems to have less anxiety and fear. Geneticists are now studying the genes responsible to uncover new potential treatments for pain relief