Weight Loss

The first human-tested weight-loss drug that burns calories through creatine-based heat generation, without reducing appetite, has successfully completed its Phase I trial. In the trial, participants lost an average of 3% fat mass in two weeks.

Weight-loss drugs like semaglutide and tirzepatide may help shrink waistlines, but new research shows they fail to boost fitness and can cause serious muscle loss, potentially undermining the long-term health benefits of slimming down.

Synching your daily calories with your own circadian rhythm can improve glucose metabolism, protecting against type 2 diabetes and obesity. A new study uncovers the relationship between metabolic health and our personal, inherent biological clock.

Cutting a single amino acid from the diet caused rapid, drastic weight loss in mice by converting white fat into calorie-burning brown fat. The study reveals a powerful new mechanism for weight loss that doesn’t rely on eating less and moving more.

Alternating between a calorie-restricted plan and one high in fat and sugar, resulting in weight gain, is not just down to psychology and behavior. This kind of weight-loss-gain cycle – yo-yo dieting – has a surprising biological driver: The gut.

A new drug from pharma company Amgen shows promise as a powerful treatment for obesity. With just a once-monthly shot of 'MariTide,' participants in the study lost as much as 16% of their body weight over the course of a year.

Over the weekend, Novo Nordisk dropped a pile of scientific data on three new experimental weight-loss drugs, including an oral one, showing what appears to be a strategic "something for everyone" plan of attack from the pharmaceutical giant.

A novel weight loss drug in the same class as semaglutide has successfully met its targets in the largest clinical trial yet, with nearly 90% of participants losing at least 5% of their body weight. The results strengthen its case for FDA approval.

A small daily dose of kombucha made from black tea has been shown to meaningfully reshape the gut microbiome in adults – particularly those with obesity – without any dietary changes. It also reveals a lot about the importance of micro-biodiversity.

Consuming too much of the dominant fatty acid in olive oil may drive the production of fat cells, creating conditions that could lead to storing more fat long-term. Until now, weight gain has been largely attributed to the calorie content of such fats.

By eliminating the essential amino acid cysteine from the diets of mice, and disabling their ability to produce it, scientists have induced rapid and dramatic weight loss. The technique opens a new pathway to explore in weight-loss science.

The first clinical trial comparing semaglutide and tirzepatide, two popular, injectable weight-loss drugs, has been published, examining their ability to reduce weight and waist circumference. And one clearly comes out on top.