Weight Loss

Scientists have found out exactly how an exercise-triggered molecule suppresses hunger signals in the brain, leading to weight loss. It could be harnessed as a therapeutic, providing the same benefit without the work it takes to produce it naturally.

Healthy eating doesn’t just shrink your waistline; it can ease chronic pain. A new study shows that better diet quality reduced pain severity and improved quality of life, independent of weight loss.

When scientists study obesity, it's often focused on genetics, physical activity and poor eating habits. However, new findings show that stress, hardship, isolation and social inequality create the biological environment that underpins the epidemic.

Large weight swings or weight loss in later life aren’t just physical health risks, they’re tied to fast memory and cognitive decline, a new study has found. It underscores the importance of weight stability for brain health in older adults.

Plant-based microbeads made from everyday ingredients like green tea and seaweed have helped mice shed weight by trapping fats in the gut. Researchers see these microbeads as a potential “structured, drug-free therapy” to treat obesity.

Researchers have successfully tweaked a specialized compound from brown seaweed to unlock its powerful anti-obesity potential. Instead of appetite suppression and fat burning, this molecule reshapes the gut microbiome to fight weight gain naturally.

It looks like we'll see oral GLP-1 drugs on the market by 2026, with Eli Lilly reporting impressive results from a large, robust 72-week trial that saw obese patients lose an average of 27.3 lb, or 12.4% of their body weight, with a once-daily pill.

The first human-tested weight-loss drug that burns calories through creatine-based heat generation, without reducing appetite, has successfully completed its Phase I trial. In the trial, participants lost an average of 3% fat mass in two weeks.

Weight-loss drugs like semaglutide and tirzepatide may help shrink waistlines, but new research shows they fail to boost fitness and can cause serious muscle loss, potentially undermining the long-term health benefits of slimming down.

Synching your daily calories with your own circadian rhythm can improve glucose metabolism, protecting against type 2 diabetes and obesity. A new study uncovers the relationship between metabolic health and our personal, inherent biological clock.

Cutting a single amino acid from the diet caused rapid, drastic weight loss in mice by converting white fat into calorie-burning brown fat. The study reveals a powerful new mechanism for weight loss that doesn’t rely on eating less and moving more.

Alternating between a calorie-restricted plan and one high in fat and sugar, resulting in weight gain, is not just down to psychology and behavior. This kind of weight-loss-gain cycle – yo-yo dieting – has a surprising biological driver: The gut.