August 8, 2006 A team of researchers from the Canadian University of Alberta researchers has created technology to regrow teeth - the first time scientists have been able to reform human dental tissue. Using low-intensity pulsed ultrasound (LIPUS), scientists have created a miniaturized system-on-a-chip that offers a non-invasive and novel way to stimulate jaw growth and dental tissue healing. The researchers are currently working on turning their prototype into a market-ready model and expect the device to be ready for the public within next two years.
"It's very exciting because we have shown the results and actually have something you can touch and feel that will impact the health of people in Canada and throughout the world," said Dr. Jie Chen, who works out of the Department of Electrical and Computer Engineering and the National Institute for Nanotechnology.
The wireless design of the ultrasound transducer means the miniscule device will be able to fit comfortably inside a patient's mouth while packed in biocompatible materials. The unit will be easily mounted on an orthodontic or "braces" bracket or even a plastic removable crown. The team also designed an energy sensor that will ensure the LIPUS power is reaching the target area of the teeth roots within the bone. TEC Edmonton, the U of A's exclusive tech transfer service provider, filed the first patent recently in the U.S. Currently, the research team is finishing the system-on-a-chip and hopes to complete the miniaturized device by next year.
"If the root is broken, it can now be fixed," said Dr. Tarak El-Bialy from the Faculty of Medicine and Dentistry. "And because we can regrow the teeth root, a patient could have his own tooth rather than foreign objects in his mouth."
The device is aimed at those experiencing dental root resorption, a common effect of mechanical or chemical injury to dental tissue caused by diseases and endocrine disturbances. Mechanical injury from wearing orthodontic braces causes progressive root resorption, limiting the duration that braces can be worn. This new device will work to counteract the destructive process while allowing for the continued wearing of corrective braces. With approximately five million people in North America presently wearing orthodontic braces, the market size for the device would be 1.4 million users.
In a true tale of interdisciplinary work, El-Bialy met Chen at the University of Alberta’s new staff orientation. After hearing about Chen's expertise in nanoscale circuit design and nano-biotechnology, El-Bialy explained his own research and asked if Chen might be able to help produce a tiny ultrasound device to fit in a patient's mouth. The two collaborated and eventually along with Ying Tsui received a grant from Natural Sciences and Engineering Research Council's "Idea to Innovation," program to expand on their prototype.
El-Bialy first discovered new dental tissue was being formed after using ultrasound on rabbits. In one study, published in the American Journal of Orthodontics and Dentofacial Orthopedics, El-Bialy used ultrasound on one rabbit incisor and left the other incisor alone. After seeing the surprising positive results, he moved on to humans and found similar results. He has also shown that LIPUS can improve jaw growth in cases with hemifacial microsomia, a congenital syndrome where one side of the child's jaw or face is underdeveloped compared to the other normal side. These patients usually undergo many surgeries to improve their facial appearance. This work on human patients was presented at the World Federation of Orthodontics in Paris, September 2005.
"After proving it worked, we looked at creating a smaller ultrasound carrier where we can take the patient out as a variable," said El-Bialy. "Before this, a patient would have to hold the ultrasound for 20 minutes a day for a year and that is a lot to ask."
