Blood-brain barrier

Antibody treatments to combat the amyloid peptides leading to Alzheimer's disease have been mostly unsuccessful. But by hiding those antibodies inside nanoparticles based on sugar, researchers have seen success in treating the symptoms in mice.

A new technique using piezoelectric nanoparticles that are activated via bursts of ultrasound has shown promise as a wire-free way to stimulate the brain. It could be used to treat Parkinson's disease and other brain-based disorders.

The brain’s natural defenses can make tumors in this part of the body difficult to treat, but scientists have found some early success using electrical fields in laboratory models that led to the selective death of tumor cells.

A newly developed, highly sensitive biosensor likened to a “deep surveillance” system has hinted at more accurate ways to diagnose brain cancer, with an ability to detect and pinpoint the location of tumors from less than a drop of blood.

The blood-brain barrier keeps your brain safe from toxins, but frustratingly it also keeps important drugs out. MIT researchers have now demonstrated an accurate new model of how this barrier works, which should enable new brain cancer treatments.

A new article has proposed a novel hypothesis for the cause of Alzheimer’s, arguing the disease is caused by a damaged blood-brain barrier allowing fatty molecules to invade the brain and trigger a cascade of events resulting in cognitive decline.

Scientists in Korea have turned their attention to the effects of microplastics on mammals by exploring the threat these particles pose to mouse brains and human cells, where they were found to act as toxic substances.

Researchers have developed microbots made of stem cells that can be delivered through the nose into the brain. These “Cellbots,” which bypass the blood-brain barrier, could one day be used to treat brain cancers and neurodegenerative diseases.

Glioblastoma is a brain cancer that can be aggressive and, unfortunately, tricky to diagnose without a biopsy. But a new noninvasive method, tested in mice and pigs, could one day diagnose the disease with ultrasound pulses and a basic blood test.

A new study has explored how the blood-brain barrier might be shored up through the use of an existing anti-cancer drug, with the authors demonstrating some promising results around reversing cognitive decline in mice.

A new molecule may help reduce side effects in a drug that could treat alcohol use disorder. Essentially, the molecule disarms the drug in most of the body, but can’t cross the blood-brain barrier, letting the drug get to work in the brain only.

A team in the UK has found new success using an experimental approach to tackle Alzheimer's, demonstrating how metal-based molecules can be combined with ultrasound and microbubbles to prevent the build up of toxic brain plaques.