A new research paper has again raised doubts over the safety and accuracy of the CRISPR-Cas9 gene editing technique. The study suggests that the gene editing process can cause extensive unforeseen and unpredictable alterations to DNA sequences outside of the intended targets.
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The CRISPR gene editing revolution is less than a decade old and scientists are still learning how best to deploy this ground-breaking technique. A team has recently discovered why the technique sometimes fails, uncovering a novel insight that will hopefully make future research more efficient.
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In one of the first examples of gene-editing technology being effectively used to knock out the expression of a gene in non-human primates, researchers have lowered the blood cholesterol in monkeys by disabling a single gene in the liver.
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A remarkable new study has successfully used the CRISPR gene editing system to edit a specific gene in mice engineered to have fragile X syndrome, a disorder often related to autism. The single gene edit in the live mice resulted in significant improvements in repetitive and obsessive behaviors.
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A team of Chinese scientists has conducted the first full assessment of the effects of CRISPR on non-human primates. The study set out to study whether the CRISPR-Cas9 genome editing technique results in off-target mutations in rhesus macaque monkeys.
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Two new studies are raising concerns that the CRISPR-Cas9 gene editing system could trigger an increased cancer risk in cells. With human trials using the technique starting this year, the scientists behind these new studies urge researchers to be aware of this cancer-driving mechanism.
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The CRISPR-Cas9 gene editing system has revolutionized medical research, but since its discovery in 2012 progress towards human trials has been slow. Now another setback has appeared with the FDA pausing one of the first human trials using the technique in the United States before it even begins.
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Allowing scientists to make cut-and-paste edits to an organism’s genome, the CRISPR gene-editing tool may be powerful, but it’s still a bit clumsy. Now, researchers have developed a neater new version dubbed MAGESTIC, which they describe as swapping the scissors for a word processor.
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A team from Duke University has used the CRISPR-Cas9 gene editing technique to switch off certain genes in mice to reduce cholesterol levels, marking the first time CRISPR has been used to silence genes – without making edits – in adult animals.
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A statement issued by the U.S. Secretary of Agriculture Sonny Perdue last week has clarified that the U.S. Department of Agriculture (USDA) currently does not, and has no plans to, regulate gene edited plants or crops.
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