CRISPR

In a historic procedure surgeons have, for the first time, transplanted a genetically modified pig heart into a living human. The patient is still alive, has not rejected the organ and is being monitored at the University of Maryland Medical Center.

Researchers in China have developed a new three-pronged method to fight liver cancer that shows promise in tests in mice. The technique combines drugs and CRISPR-Cas9 gene editing into lipid nanoparticles, then activates them with ultrasound.

Scientists have used the CRISPR gene-editing system to produce litters of mice that are 100 percent either male or female. The technique could help prevent the unnecessary culling of animals of unwanted sex in agriculture or scientific experiments.

Scientists have successfully used CRISPR and phages to edit the genome of bacteria in the gut microbiome of live mice for the first time. The breakthrough could help manipulate the ratio between different species to treat a range of health problems.

Scientists working to improve crop yields in the face of climate change continue to demonstrate how CRISPR could be pivotal, and a new study shows how the technology can be used to produce a mutant species of barley that sprouts at the right time.

Lizards can regrow their tails, but the new tail isn't quite perfect. Scientists have now used stem cell therapy to let lizards grow better tails – bones, nerves and all – in an advance that could have implications for better wound healing in humans.

The CRISPR gene-editing system is built on a bacterial defense mechanism that allows scientists to make precise edits to DNA. Now scientists at MIT have discovered a new class of enzymes called OMEGAs that perform a similar function, perhaps better.

A new company called Colossal plans to revive the woolly mammoth and reintroduce the species to the Arctic. And it isn’t meant to be just a tourist-trap Jurassic Park either – the aim is to restore a long-lost ecosystem to help fight climate change.

The CRISPR gene-editing system is usually associated with the Cas9 protein, but that’s not the only option. Stanford scientists have now developed a CRISPR tool called CasMINI, using a much smaller protein that's able to enter human cells more easily.

Data from the United States’ first CRISPR clinical trial indicates the treatment is safe and effective two years after initial dosing. Targeting a pair of rare blood diseases, the therapy has so far been 100 percent effective in all 22 patients treated.

Sugarcane is a key food crop, but its large environmental impact leaves plenty of room for improvement. Unfortunately it’s tricky and time-consuming to breed new varieties, but now researchers have used CRISPR gene-editing to do so more easily.

The CRISPR gene-editing tool has been successfully used in space for the first time. Researchers onboard the International Space Station have edited colonies of yeast to study how they repair DNA damage, which could one day help protect astronauts.