CRISPR

Sugarcane is a key food crop, but its large environmental impact leaves plenty of room for improvement. Unfortunately it’s tricky and time-consuming to breed new varieties, but now researchers have used CRISPR gene-editing to do so more easily.

The CRISPR gene-editing tool has been successfully used in space for the first time. Researchers onboard the International Space Station have edited colonies of yeast to study how they repair DNA damage, which could one day help protect astronauts.

New clinical data shows that CRISPR gene editing can be done safely and effectively inside the body. CRISPR was injected into the bloodstream of patients with a genetic disease, with better outcomes than current treatments and no side effects.

A new proof-of-concept study suggests CRISPR gene therapy may be a promising alternative to opioids for chronic pain. The preliminary investigation demonstrated lowered pain sensitivity in mice after temporarily repressing activity of a specific gene.

One of the most promising emerging cancer therapies is CAR T cell immunotherapy, where a patient’s own immune cells are supercharged to fight tumors. Now researchers have found a way to refresh exhausted immune cells and get them back into battle.

A rapid COVID-19 test promises accurate results in under 30 minutes using a simple hand-held device, a nasal swab and a smartphone camera. The technology can also be modified to detect other viral diseases.

Getting CRISPR into cells can be challenging. Now Australian researchers have packaged the tool inside porous materials called metal organic frameworks (MOFs) coated in a green tea compound, and used it to silence key genes in prostate cancer cells.

The 2020 Nobel Prize in Chemistry has been awarded to the two scientists who discovered and refined the CRISPR/Cas9 gene-editing tool. This allows for relatively simple editing of genes and could revolutionize medicine, agriculture and other fields.

In a wonderful case of blending an ancient therapy with modern tech, scientists gene edited the Leishmania major parasite to limit its infectivity. This allows the parasite to be given to patients in a vaccine, creating immunity without causing disease.

In a breakthrough that promises to revolutionize the precision breeding of animals, scientists have used the CRISPR gene editing tool to produce infertile animals that become "surrogate sires" and produce sperm containing only donor animal DNA

By tweaking the CRISPR gene-editing technique to target RNA instead of DNA, researchers have been able to destroy toxic accumulations of this molecule, which could pave the way for new treatments for muscular dystrophy and related conditions.

Researchers have, for the first time, successfully gene edited a cephalopod. Using CRISPR-Cas9 technology, the research breakthrough will now allow scientists to conduct novel investigations into medical, robotic, and materials innovations.