Insulin

The results of a clinical trial offer promising signs that daily doses of an insulin nasal spray could be used to slow age-related cognitive decline. The trial found the treatment to be effective in elderly subjects with and without type 2 diabetes.

A preclinical study has demonstrated, across several animal studies, how an experimental drug can treat type 2 diabetes by increasing the expression of a recently discovered protein found to influence insulin signaling in cells.

Scientists have now identified a cellular pathway that can contribute to the death of insulin-producing cells. They found that blocking it in mice and human cells keeps the beta cells alive for longer, delaying or preventing the onset of diabetes.

Diabetics typically have to receive insulin via daily injections, or sometimes even from implanted pumps. According to a new study, however, a simple inner-cheek patch could one day provide a far less painful and invasive alternative.

Insulin regulates blood glucose levels, and issues often lead to diabetes. But now, scientists at the Salk Institute have identified another molecular pathway that regulates blood glucose, which could open up a brand new avenue for treating diabetes.

Scientists at Harvard University have made a breakthrough that implicates a newly discovered hormone in the onset of diabetes, and shown how it can be targeted to reverse the effects of the disease.

New studies are reporting results from a type 1 diabetes human clinical trial testing a device containing stem cells designed to mature into insulin-secreting cells. The experimental implant was found to be safe, well-tolerated and mildly effective.

Yale researchers have developed a new oral medication for type 1 diabetes. In tests in mice, the drug quickly adjusted insulin levels, restored metabolic functions and reversed inflammation, opening up a potential way to prevent the disease.

A new study has explored how damaged, lingering cells called senescent cells can negatively influence the behavior of fat cells, and demonstrated how their removal can alleviate diabetes symptoms in obese mice.

A team of scientists in the US investigating the relationship between metabolic syndrome and a key hormone have demonstrated how a promising new drug could play an important preventative role in a variety of conditions, including obesity and diabetes.

A peptide called MOTS-c shows promise in preventing type 1 diabetes, in new tests in human cells in culture and live mice. The peptide regulates the immune system, potentially leading to treatments for type 1 diabetes and other autoimmune diseases.

An artificial pancreas has been trialed in patients with type 2 diabetes for the first time. The device monitors a person’s blood glucose levels and automatically administers insulin when needed – and the results so far are promising.