In a remarkable proof-of-concept study, scientists from the University of Pennsylvania and the Children’s Hospital of Philadelphia have, for the first time, successfully used CRISPR gene-editing technology on mice in utero, to prevent the animals being born with a lethal metabolic disorder.
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New research has revealed that fisetin – a natural flavonoid found in many fruits and vegetables – functions as an effective senolytic agent by clearing out damaged aging cells, improving health and extending lifespan.
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It’s long been believed that cytomegalovirus (CMV) probably weakens the immune system in older people, but now mice tests have shown that the opposite is true – somehow, the virus gives the immune system a bit of a late-stage boost.
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The field of optogenetics is all about using light to stimulate cells in the body. Now, researchers from Flinders University have used the technique to shine a light where the Sun don’t shine, stimulating nerves in the gut to relieve chronic constipation.
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Researchers from MIT have found that fasting for just 24 hours is enough to improve the regeneration of a person’s intestinal stem cells, which naturally declines with age. Better yet, with the metabolic switch identified, in the future the effect could be mimicked with a drug.
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A new study has found a way to completely stop a body’s ability to store fat. In experiments with mice, researchers showed that genetically deleting a single enzyme resulted in the animal not being able to gain weight, even when fed a fatty diet.
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Rresearchers at the University of Michigan have found a way to retrain the immune system to ignore allergens by developing a nasal spray that vaccinates against peanut allergies, with promising results in mouse tests.
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Researchers from Washington University have tested a new weapon in the fight against Alzheimer’s. In mice, the team has demonstrated an antibody that can clear away the disease’s build-up of proteins in the brain, which may lead to an early-stage treatment to prevent symptoms from occurring.
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Fat may be a villain of our time, but it’s not fair to paint it all with the same brush. Researchers at the Salk Institute have identified the protein that allows brown fat to expend energy, opening up a new potential avenue for treating obesity and its related diseases.
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Researchers have developed a new stem-cell-based treatment for strokes. When tested in animal models, the technique was found to reduce brain damage and help the brain heal itself faster, and the results have been promising enough that clinical human trials may follow as soon as next year.
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