Weight Loss

A research review published in the journal Frontiers in Nutrition argues popular low-carbohydrate ketogenic diets are unhealthy for most people. The review rekindles a long-standing debate over the dangers of high-fat/low-carb dietary strategies.

Scientists have stumbled across a mechanism by which the immune system triggers the secretion of fat cells through the skin. The mechanism may translate from mice into humans, but turning it into a safe obesity therapy could be challenging.

UK and University of Otago researchers have presented a "world-first weight loss device," which attaches to the teeth and prevents patients from opening their mouths wider than 2 mm using "magnetic devices and custom-manufactured locking bolts."

A new study investigating how a low-calorie diet alters gut microbial populations is reporting unexpected results, finding a strange relationship between extreme caloric restriction and increased levels of a bacteria linked to inflammatory bowel disease.

A new systematic review of over 300 clinical trials has found little to no evidence any of over-the-counter weight loss supplements actually work, and the researchers are calling on regulatory authorities to take action.

A trial led by researchers from the University of Bath questions the value of popular fasting diets, finding a simple calorie-controlled diet is more effective at reducing weight. The trial also found fasting can lead to greater losses of muscle mass.

The US Food and Drug Administration has approved a new weight management drug called Wegovy (semaglutide). First approved as a type 2 diabetes treatment in 2017, the drug has been described as a “game-changer” for obese or overweight adults.

Researchers have identified an entirely new neural circuit that can be targeted to trigger satiation in mice, and even found that an already-approved ADHD drug confers its weight loss effects through this same pathway.

Researchers are continuing to unravel the relationship between inflammation and obesity, and through new study involving overweight mice and a repurposed heart disease drug, scientists have uncovered new evidence of how the two are closely connected.

A striking new study testing a number of over-the-counter weight loss and sports supplements has found they contain many combinations of stimulants that have either previously been prohibited by the FDA or never approved for human consumption.

In what the authors are hailing as a “game-changer” in the realm of weight loss therapy, a major global study has demonstrated how an obesity drug can help cut significant body weight from many of those who take it.

When an obese person really needs to lose weight, gastric bypass surgery is sometimes performed – but it's quite an invasive procedure. An experimental new implant, however, may produce similar results with much less fuss.