Italian doctor may have found surprisingly simple cure for Multiple Sclerosis

Italian doctor may have found surprisingly simple cure for Multiple Sclerosis
Left: diagram from a medical text showing how MS affects the myelin sheathing of nerves. Right: MS lesions under a microscope.
Left: diagram from a medical text showing how MS affects the myelin sheathing of nerves. Right: MS lesions under a microscope.
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Left: diagram from a medical text showing how MS affects the myelin sheathing of nerves. Right: MS lesions under a microscope.
Left: diagram from a medical text showing how MS affects the myelin sheathing of nerves. Right: MS lesions under a microscope.

An Italian doctor has been getting dramatic results with a new type of treatment for Multiple Sclerosis, or MS, which affects up to 2.5 million people worldwide. In an initial study, Dr. Paolo Zamboni took 65 patients with relapsing-remitting MS, performed a simple operation to unblock restricted bloodflow out of the brain - and two years after the surgery, 73% of the patients had no symptoms. Dr. Zamboni's thinking could turn the current understanding of MS on its head, and offer many sufferers a complete cure.

Multiple sclerosis, or MS, has long been regarded as a life sentence of debilitating nerve degeneration. More common in females, the disease affects an estimated 2.5 million people around the world, causing physical and mental disabilities that can gradually destroy a patient's quality of life.

It's generally accepted that there's no cure for MS, only treatments that mitigate the symptoms - but a new way of looking at the disease has opened the door to a simple treatment that is causing radical improvements in a small sample of sufferers.

Italian Dr. Paolo Zamboni has put forward the idea that many types of MS are actually caused by a blockage of the pathways that remove excess iron from the brain - and by simply clearing out a couple of major veins to reopen the blood flow, the root cause of the disease can be eliminated.

Dr. Zamboni's revelations came as part of a very personal mission - to cure his wife as she began a downward spiral after diagnosis. Reading everything he could on the subject, Dr. Zamboni found a number of century-old sources citing excess iron as a possible cause of MS. It happened to dovetail with some research he had been doing previously on how a buildup of iron can damage blood vessels in the legs - could it be that a buildup of iron was somehow damaging blood vessels in the brain?

He immediately took to the ultrasound machine to see if the idea had any merit - and made a staggering discovery. More than 90% of people with MS have some sort of malformation or blockage in the veins that drain blood from the brain. Including, as it turned out, his wife.

He formed a hypothesis on how this could lead to MS: iron builds up in the brain, blocking and damaging these crucial blood vessels. As the vessels rupture, they allow both the iron itself, and immune cells from the bloodstream, to cross the blood-brain barrier into the cerebro-spinal fluid. Once the immune cells have direct access to the immune system, they begin to attack the myelin sheathing of the cerebral nerves - Multiple Sclerosis develops.

He named the problem Chronic Cerebro-Spinal Venous Insufficiency, or CCSVI.

Zamboni immediately scheduled his wife for a simple operation to unblock the veins - a catheter was threaded up through blood vessels in the groin area, all the way up to the effected area, and then a small balloon was inflated to clear out the blockage. It's a standard and relatively risk-free operation - and the results were immediate. In the three years since the surgery, Dr. Zamboni's wife has not had an attack.

Widening out his study, Dr. Zamboni then tried the same operation on a group of 65 MS-sufferers, identifying blood drainage blockages in the brain and unblocking them - and more than 73% of the patients are completely free of the symptoms of MS, two years after the operation.

In some cases, a balloon is not enough to fully open the vein channel, which collapses either as soon as the balloon is removed, or sometime later. In these cases, a metal stent can easily be used, which remains in place holding the vein open permanently.

Dr. Zamboni's lucky find is yet to be accepted by the medical community, which is traditionally slow to accept revolutionary ideas. Still, most agree that while further study needs to be undertaken before this is looked upon as a cure for MS, the results thus far have been very positive.

Naturally, support groups for MS sufferers are buzzing with the news that a simple operation could free patients from what they have always been told would be a lifelong affliction, and further studies are being undertaken by researchers around the world hoping to confirm the link between CCSVI and MS, and open the door for the treatment to become available for sufferers worldwide.

It's certainly a very exciting find for MS sufferers, as it represents a possible complete cure, as opposed to an ongoing treatment of symptoms. We wish Dr. Zamboni and the various teams looking further into this issue the best of luck.

Via The Globe and Mail.

Update (Feb. 10,2014): A study conducted by researchers at the University of Buffalo has cast doubt the validity of this approach.

Facebook User
A very positive development, thanks to my Italian brethren!... toot-toot!
Gonzalo Villouta Stengl
An amazing new, and an amazing information tool as well. Worth any web surfing time to delight you discovering top research and insights on science and technology.
Best wishes.
Jennifer Zordan
God willing.
I hope this works out, but something is setting off my skeptic alarm.
For one thing, 73% of 65 people is 47.45 people. So lucky Mr. 48 was cured on his right side only?
Anyway, I look forward to more detail.
David Mahan
You\'ve got to wonder how many other such simple procedures there are???!!!
Ted Nehme
What is disturbing is the fact that fellow Mser\'s are so desperate for a cure that they tend do avoid asking the right questions when it comes to these \"miracles\". What if 95% or so people with MS have this condition because it\'s a cause/symptom of MS, and not the cause of MS? I do not want to seem pessimistic, but I would reserve judgment for when more data is available.
This wouldn\'t be the first time excess iron has been implicated in disease. It\'s well known that too much iron is a risk factor in atheroschlerosis, which is why male-specific multivitamin supplements no longer contain iron. There\'s even some evidence excess iron increases the risk of cancer.
Joe's Cat
65 people plus his wife makes it 66 people.
73% makes it 48.18 people.
I think the reporter probably meant \"more than 72%\" and then simplified by writing in 73 instead of writing in 72.7272%
Mario Maio
...and that\'s not the only new from italy; there is a young guy, Matteo Dall\'Osso ( ), who healed himself from MS against all doctor\'s opinion (except Dr. Zamboni, who helped him too), just by depuring (in a special way) his body from metals (he has got a metabolic disease that avoid his body to dispose off metals at a normal rate). So it seems that MS could be the result of metallic accumulation in the body, due to a cause (vein occlution) or another (metabolic disfunction). The real risk about these MS treatments is that they are too economical, simple and they were not discovered by a big pharmaceutic multinational; big opposing economic interests are able to prevent the diffusion of such discovers. Help the web spread the good news.
Mario Maio
please adjust my previous post with the following link to english version of Matteo Dall\'Osso web site
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