Blood-brain barrier
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Researchers have developed microbots made of stem cells that can be delivered through the nose into the brain. These “Cellbots,” which bypass the blood-brain barrier, could one day be used to treat brain cancers and neurodegenerative diseases.
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Glioblastoma is a brain cancer that can be aggressive and, unfortunately, tricky to diagnose without a biopsy. But a new noninvasive method, tested in mice and pigs, could one day diagnose the disease with ultrasound pulses and a basic blood test.
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A new study has explored how the blood-brain barrier might be shored up through the use of an existing anti-cancer drug, with the authors demonstrating some promising results around reversing cognitive decline in mice.
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A new molecule may help reduce side effects in a drug that could treat alcohol use disorder. Essentially, the molecule disarms the drug in most of the body, but can’t cross the blood-brain barrier, letting the drug get to work in the brain only.
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A team in the UK has found new success using an experimental approach to tackle Alzheimer's, demonstrating how metal-based molecules can be combined with ultrasound and microbubbles to prevent the build up of toxic brain plaques.
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Getting traditionally administered drugs into the brain can be challenging, due to the body's protective blood-brain barrier. There may be new hope, however, in the form of a patch that gets shoved up the patient's nose.
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Getting drugs into the brain is no easy feat, but the nose is one of the most direct routes. Now, UK researchers have developed a nasal spray hydrogel that lines the tissue in the nose to deliver a common Parkinson’s drug straight to the brain.
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Research into a rare type of dementia has uncovered a genetic mutation that results in dysfunctional white blood cells and a breakdown of the blood-brain barrier, a mechanism that may play a role in common types of dementia such as Alzheimer's.
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A new particle that borrows chemical passports from neurotransmitters to slip through the blood-brain barrier could open up new avenues of treatment, with the technique showing promise as a way of tackling Alzheimer’s and other conditions.
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The brain’s own defense mechanism often prevents treatment of brain cancers. But a new experimental treatment has shown success in mice, with carbon nanoparticles able to sneak through the blood-brain barrier and deliver drugs directly to tumors.
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A new study from Northwestern University is demonstrating evidence a novel implantable ultrasound device allows a less toxic formulation of chemotherapy to cross the blood-brain barrier and destroy deadly tumors.
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Two compelling new studies are building on a hypothesis suggesting age-related dementia is caused by a leaky blood-brain barrier. Experts suggest the studies are interesting but not particularly applicable to human cases of dementia.
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