clinical trials

Scientists have failed to show that weight-loss wonder drug semaglutide can also slow the progress of Alzheimer's disease (AD), as two two-year clinical trials end in disappointment for patients, medical scientists and drugmaker Novo Nordisk.

In a Phase 3 trial of more than 18,000 volunteers across three countries, a novel mRNA influenza vaccine developed by Pfizer has outperformed standard seasonal flu shots by 34.5%. It's yet another sign that this biotechnology is here to stay.

In a world-first trial, scientists used a one-off CRISPR gene edit to switch off a liver “fat brake” gene, slashing stubborn LDL cholesterol and triglycerides in patients whose levels refused to budge on standard treatments.

Scientists who won a 2024 IgNobel Prize for "discovering that many mammals are capable of breathing through their anus" have now completed a successful trial based on this, using a technique that gets oxygen into the blood via an unconventional route.

A new drug combination to treat advanced recurring prostate cancer has shown remarkable results in a long-term trial, lowering the risk of death after eight years by 40.3%. What's more, the drug treatments are already FDA-approved on their own.

A new oral drug may become the first prescription pill specifically designed to regrow hair in both women and men – and without the cardiac risks. Currently in Phase 3 trials, it could be the first new treatment for pattern hair loss in nearly 30 years

A one-time gene therapy using a patient’s own stem cells has effectively cured a deadly immune disorder in 95% of treated children, offering a lasting, donor-free solution to ADA-SCID, known as the “bubble boy” disease.

A new class of weight-loss drug has shown it can significantly boost weight loss when paired with GLP-1 therapy – without adding side effects – in a mid-stage clinical trial, pointing to a powerful new combination approach to tackling obesity.

A once-daily pill for ulcerative colitis has delivered strong results in a clinical trial, easing symptoms even in patients for whom other treatments had failed and raising hopes for a safer, more effective therapy for a condition that affects millions.

Precision-targeted radiation is proving a match for surgery in early-stage lung cancer, offering patients similar long-term survival with less invasiveness, and potentially transforming how this common cancer is treated.

Psoriasis may not have a cure, but significant relief might be found at the dinner table. A clinical trial has shown that the Mediterranean diet could dramatically improve symptoms, quality of life and overall health of those with the condition.

An existing transplant drug has shown promise in slowing the progression of type 1 diabetes in newly diagnosed young people, potentially paving the way for the first therapy that modifies the disease after diagnosis.