Drug delivery

Although scientists have been working on "microbots" that could deliver drugs within the body, one challenge remains – powering the things without the use of bulky onboard batteries. A new approach utilizes ultrasound waves that act on tiny bubbles.

Klebsiella pneumoniae is a nasty bacteria that can cause pneumonia. It’s a tough one to fight, but now researchers have developed an inhalable vaccine that, in mouse tests, can invoke a strong immune response against several strains of the bacteria.

Researchers have developed particles called dendrimers that are covered in tiny tentacles, arranged in patterns too small for the immune system to detect. These could be handy for delivering drugs or camouflaging implants to prevent rejection.

Various groups are currently working on tiny "robots" that could deliver medication to specific locations within the body. One of the latest such microbots, known as the MANiAC, is designed specifically for use in the delicate central nervous system.

Researchers in Germany have developed a new method to treat viral infections by making traps. The team folded DNA into nano-capsules with specialized binding points inside them, which could grab hold of viruses and render them inert.

Getting traditionally administered drugs into the brain can be challenging, due to the body's protective blood-brain barrier. There may be new hope, however, in the form of a patch that gets shoved up the patient's nose.

Patients don't like getting needles, nor do clinicians like having to keep protein-based vaccines cold at all times. A new polymer wafer – which dissolves when placed under the tongue – could address both issues.

Although there are implants that gradually release medication at specific sites within the body, it can be difficult to control their rate of release. An experimental new device, however, dispenses drugs when externally activated by a shockwave.

Getting drugs into the brain is no easy feat, but the nose is one of the most direct routes. Now, UK researchers have developed a nasal spray hydrogel that lines the tissue in the nose to deliver a common Parkinson’s drug straight to the brain.

Nobody likes needles, but they’re a necessary evil. Microneedle patches are emerging as a painless alternative, and now researchers in Hong Kong have developed a new version of the tech that’s made of ice, for easier manufacture and use.

An oral pill would be much easier for diabetics than daily insulin injections. An experimental new method for packing insulin into capsules helps it survive the trip through the stomach to the bloodstream, and releases its payload only when needed.

A team at McGill University has come up with novel kind of suture that is based on human tendons, which enables it to not only heal wounds more effectively, but possibly even monitor their progress and be loaded with drugs to stave off infection.