RNA

Researchers have demonstrated a new technique for helping heart cells regenerate after a heart attack, using mRNA to return the cells to a stem-cell-like state. Tests in mice showed drastic improvements to heart function a month after a heart attack.

Evidence is mounting that the key building blocks of life may have been delivered to our home planet from space. Scientists have now identified in meteorites the last two DNA nucleobases that hadn’t yet been found in extraterrestrial samples.

In phase 1 trials, an RNA gene therapy has shown promise for reducing levels of a lipoprotein associated with a high risk of heart disease. The treatment could help fight a form of the disease that can’t currently be treated through lifestyle changes.

Researchers at the University of Tokyo have created an RNA molecule that can not just replicate, but “evolve” into a diverse range of more complex molecules. This find could plug a major gap in the puzzle of how life on Earth began.

A study from scientists at MIT has demonstrated a way to deliver mRNA directly to the digestive tract using a novel capsule. The researchers indicate this oral delivery system could be a unique way to administer mRNA therapies directly to the stomach.

More advances on the mRNA vaccine front this week as Pfizer and Moderna move forward on new viral targets for future vaccines. Pfizer is turning its focus to shingles while Moderna begins human trials for a mRNA vaccine against the Epstein-Barr Virus.

A new kind of COVID-19 treatment is designed to stimulate the body’s immune defenses and fight off a coronavirus infection at its earliest stages. In preclinical animal tests a synthetic RNA molecule helped mice effectively clear the virus.

How life first emerged from non-living matter is one of the most enduring mysteries of science. In a new study, scientists have created self-replicating protocells in the lab, which could represent the “missing link” between chemistry and biology.

The CRISPR gene-editing system is built on a bacterial defense mechanism that allows scientists to make precise edits to DNA. Now scientists at MIT have discovered a new class of enzymes called OMEGAs that perform a similar function, perhaps better.

Sharing information is crucial for species to survive, but how do simple lifeforms like worms spread the word? New research has found that roundworms can transfer “memories” to their neighbors, and pass them down to their offspring for generations.

The results of a Phase 3 trial testing Moderna’s COVID-19 vaccine in 12 to 17 year olds have been published in The New England Journal of Medicine. The study indicates the vaccine is as safe and effective as it was previously found to be in adults.

New data from Moderna is showing its mRNA COVID-19 vaccine remains significantly effective after six months. However, the company does note a reduction in efficacy from the Delta variant indicates a likely need for third dose boosters later in 2021.