Wyss Institute

A new breakthrough could help unravel the immune system's secrets. Researchers have created an accurate model of the human immune system in a microfluidic chip, providing a better platform to study how immune cells respond to vaccines and pathogens.

Animals like axolotls can regrow fully functional replacements for lost limbs. In a breakthrough new study, scientists have demonstrated how one dose of a drug cocktail can regrow lost limbs in frogs that don’t normally have regenerative abilities.

A new slug-inspired biomaterial improves tendon healing, with one sticky side and a low-friction outer surface that keeps it gliding against other tissues. Better yet, they can be loaded with slow-release drugs to reduce scarring and inflammation.

Scientists have developed first-of-a-kind "Xenobots" from frog cells with the ability to self-replicate, a technology that could find use in regenerative medicine and and reveals a type of biological reproduction never before observed in science.

Eardrum perforations are painful, impair hearing and are tricky to repair. The PhonoGraft, developed at Harvard, is a 3D-printed implant that can patch up damage by encouraging natural cells to regrow, and now it’s ready for commercial production.

Scientists at Harvard have demonstrated an alternative to CRISPR – a genetic engineering system called Retron Library Recombineering (RLR) that works without cutting DNA and can be quickly applied to huge populations of cells.

Using AI to spot melanoma in its early stages is an exciting possibility, and a new deep-learning system developed by Harvard and MIT scientists promises a new level of sophistication, by using a method known as the “ugly duckling” criteria.

Cancer spreads easily, and a common location for secondary tumors to appear is the lungs. Now, scientists at Harvard’s Wyss Institute have developed a way to treat metastatic tumors in the lungs, by attaching immune-baiting drugs to red blood cells.

A new tennis-ball-sized machine developed in a Harvard-Sony collaboration could open up some interesting new pathways in the field of robot-assisted surgery, with the ability to handle delicate tasks on a microscopic scale.

Researchers at Harvard have developed a new platform for producing vaccines. Red blood cells are loaded with antigens to generate a specific immune response, and in tests in mice the team showed that it was effective in slowing the growth of cancer.

In 2017, researchers demonstrated a soft robotic exosuit designed to help stroke patients improve their mobility. Now an untethered version of the lightweight ankle-assisting device has been shown to increase walking speed and distance.

Scientists at Harvard have come up with a new way to supercharge immune cells that are one of our key defenses against cancerous cells, equipping them with a type of “backpack” that slows tumor growth in mice with an aggressive form of breast cancer.