Biology

Scientists create world's first biologically powered computer chip

Having isolated a biological process and used it to power an integrated circuit, researchers are now looking at ways to scale down the system, and look for ways to manage biological decay
Having isolated a biological process and used it to power an integrated circuit, researchers are now looking at ways to scale down the system, and look for ways to manage biological decay
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Having isolated a biological process and used it to power an integrated circuit, researchers are now looking at ways to scale down the system, and look for ways to manage biological decay
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Having isolated a biological process and used it to power an integrated circuit, researchers are now looking at ways to scale down the system, and look for ways to manage biological decay
Illustration depicting biocell attached to CMOS integrated circuit with membrane containing sodium–potassium pumps in pore
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Illustration depicting biocell attached to CMOS integrated circuit with membrane containing sodium–potassium pumps in pore

The dream of melding biological and man-made machinery is now a little more real with the announcement that Columbia Engineering researchers have successfully harnessed a chemical energy-producing biological process to power a solid state CMOS integrated circuit.

According to study lead professor Ken Shepard, this is the world's first successful effort to isolate a biological process and use it to power an integrated circuit, much like the ones we use in phones and computers.

The researchers developed the system by using an artificially created lipid bilayer membrane containing naturally occurring ion pumps, which are powered by the biological world's "energy currency molecule," ATP (adenosine triphosphate). ATP is the coenzyme that transfers chemical energy between living cells. It is an end product of processes such as photosynthesis and cellular respiration, and it powers the mechanical work of living systems such as cell division and muscle contraction.

The scientists connected the lipid membrane to a conventional solid-state complementary metal-oxide-semiconductor (CMOS) integrated circuit, and the ion pumps powered the circuit.

"Ion pumps basically act very similarly to transistors," Shepard tells Gizmag. "The one we used is the same kind of pump that is used to maintain the resting potential in neurons. The pump produces an actual potential across an artificial lipid membrane. We packaged that with the IC and we used the energy across that membrane due to those pumped ions to power the integrated circuit."

Illustration depicting biocell attached to CMOS integrated circuit with membrane containing sodium–potassium pumps in pore
Illustration depicting biocell attached to CMOS integrated circuit with membrane containing sodium–potassium pumps in pore

Using an isolated and artificially created biological component is a different approach to interfacing whole living systems with chips, which was done in the past with varying success.

"We don't need the whole cell [now]," Shepard says. "We just grab the component of the cell that's doing what we want. For this project, we isolated the ATPases because they were the proteins that allowed us to extract energy from ATP."

Shepard says the team is excited about the prospect of extending the range of possibilities in electronics.

"As technology scaling ends, we have to be a little bit more creative and expansive in the way we define an electronic device and the material systems that we use to create electronic devices," he says. "How do we expand the palette? That's essentially what this work is about."

The key challenges now are to try to scale the system down, and to look for ways to manage biological decay.

Challenges aside, the potential for combining biological and electronic processes certainly fires the imagination.

"100 Intel designers couldn't design a system that could tell if there's a skunk in the room or not, and the best synthetic biologists in the world couldn't build a radio," quips Shepard. "But if we can just use the piece of the biological process that we want and use its function with solid state electronics, we'll get that enhanced functional palette of capabilities that don't exist with chips alone."

The research was recently published in Nature Communications.

Source: Columbia University

8 comments
Mel Tisdale
This needs to be carefully watched. The potential is enormous, but not all of it good.
2_OK
Not sure, however I would like to be less dependent on electricity consumption in my home, this sound more promising. I am also concerned about some things regarding the environmental issues. It is all strange, and I know it for the fact that there are so many technologies available in USA and SSSR files and some other countries and they just don't use it. ! For the sake of the GOD and all living people, could we just switch to those better options, it is in all of our interest after all.
Catweazle
"This needs to be carefully watched. The potential is enormous, but not all of it good." Mel Tisdale The same could be said for absolutely any invention whatsoever, every coin has two faces. It's a good job you weren't about in the Stone Age Mel, else we'd never have invented sharp tools, think of the potential for cutting one's self. As for inventing the wheel... I bet you're real fun at parties!
Gorntrex
This is absolutely insane! I'm a struggling student 1/2 neuroscience and 1/2 electrical engineering and this is blowing my mind. The only way I can imagine this can going, to solve the decay part, will be to give the bi-layer more biological components to repair/recycle. In the end it could end up like a primitive man made cell working away in your phone. Inspiring, to see the merging of these vocations into something so creative, it makes my academic struggle feel worth it.
John Banister
So, if a device could pick up ATP from the bloodstream and charge batteries, would the body respond by getting more ATP out of fat cells?
techmaster
Great achievement but still a way to go before it can be practically used. One square cm will give a few nano amps current, which is not enough to be very useful for circuit design. The efficiency needs to be increased further and issues like fibrous tissue growth after implantation also need to be addressed.
bwana4swahili
Human's have the greatest capacity to recreate what nature has done over millions of years; however, this is one more step in our ultimate evolution to "homo machinicus"...
warren52nz
So eventually our phones won't say "Charge Me" they'll say "Feed Me".
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