Health & Wellbeing

Psilocybin alcoholism trial highlights problem for psychedelic science

Psilocybin alcoholism trial highlights problem for psychedelic science
Almost every participant in the trial guessed whether they had been given psilocybin or placebo, raising questions over whether psychedelic trials can ever be properly blinded
Almost every participant in the trial guessed whether they had been given psilocybin or placebo, raising questions over whether psychedelic trials can ever be properly blinded
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Almost every participant in the trial guessed whether they had been given psilocybin or placebo, raising questions over whether psychedelic trials can ever be properly blinded
Almost every participant in the trial guessed whether they had been given psilocybin or placebo, raising questions over whether psychedelic trials can ever be properly blinded

A new study published in JAMA Psychiatry has reported results from the first ever double-blind, placebo-controlled trial testing psilocybin-assisted psychotherapy to treat alcohol use disorder. The headline results are promising, finding nearly half of the psilocybin group stopped drinking altogether after the treatment. However, with almost every participant breaking blind and guessing whether they were given an active drug or placebo, the study raises major questions about the veracity of these kinds of clinical trials for psychedelic drugs.

The new trial, led by a team from NYU Grossman School of Medicine, enrolled 93 subjects with clinically diagnosable alcohol use dependence. The cohort was evenly randomized into either a psilocybin group or a placebo control.

All subjects, including those in the placebo group, underwent a psychotherapeutic protocol spanning several months: four sessions before starting any psychedelic treatment, four sessions between the first and second drug treatment, and four sessions at the end.

Those in the placebo group were given what is known as an active placebo. In this case it was an anti-histamine called diphenhydramine, which in high doses can generate feelings of being flushed or even euphoria.

At the eight-month follow-up the study found 48% of those in the psilocybin group had stopped drinking completely, compared to 24% in the placebo group. In terms of reductions in "heavy drinking" (defined as days where more than four to five alcohol drinks were consumed), those in the psilocybin group had dropped their number of heavy drinking days by 83%, compared to a 51% drop in the placebo.

The study’s results are undeniably promising. Using LSD to treat alcoholism was one of the first therapeutic targets explored by researchers back in the 1950s, and there is a relatively rich vein of older work exploring this modality. But these new findings do highlight some significant unresolved problems within the field of modern psychedelic clinical research.

A randomized, blinded, control trial is the gold standard of modern research. Getting two groups of people together to test an intervention, but blindly giving one group a placebo, is a crucial way scientists can gather empirical evidence as to whether a novel treatment fundamentally works.

But in psychedelic science it can be virtually impossible to give someone an inactive placebo without them realizing pretty quickly they haven’t been given the real drug. Over the last few years this problem has been cited as potentially leading to over-inflated effects in psychedelic clinical trials.

In this new study, the NYU researchers noted virtually every subject correctly guessed whether they were given psilocybin or placebo. By the second drug session, nearly 95 percent of participants had guessed correctly which group they had been assigned.

Not only did the study participants effectively “break blind,” but the study therapists, who were also blinded, ultimately guessed the treatment groups. By the second drug session the therapists correctly guessed which patients had been given placebo and which psilocybin with 97.4% accuracy.

So, considering the attempt to double-blind this study completely failed, it seems slightly disingenuous to even frame the study as blinded. The fourth line of a press release from NYU Langone Health announcing the study explicitly states, "Neither the researchers nor the study participants knew which medication they received." A fact that may have been true at the beginning of the research but was certainly not true by the end.

Senior author on the new study Michael Bogenschutz said using the antihistamine diphenhydramine as an active placebo was the team’s attempt at overcoming this problem.

“In this case we weren’t terribly successful in maintaining the blind,” Bogenschutz admitted. “Most people were able to guess what medication they received. We don’t necessarily have a better placebo condition in mind. So it kinda comes with the territory when the drug you’re using has very active, overt psychological effects that are easily distinguished.”

In announcing the new study results at a press conference the researchers introduced two participants from the trial. Both men spoke enthusiastically about their positive experiences, each basically quitting drinking after the trial.

But in a strange moment late in the press conference it was revealed, via a journalist question, that one of the two participants was actually from the placebo group. Paul Mavis, who had glowingly described the treatment earlier in the press conference as “significant” and “game-changing,” subsequently stressed the importance of the psychotherapy in his positive experience from the trial.

Mavis also stressed he didn’t know he had been given a placebo until literally a week ago, when he was approached to take part in this press conference, making him one of the the very few participants in the trial to not correctly guess their group assignment. All subjects in the trial were offered a third drug session with psilocybin, so those in the placebo group ultimately did experience a psychedelic session.

Mavis said even after being given a real dose of psilocybin, he still didn't guess his first two sessions had been with a placebo. He simply interpreted the acute psychedelic experience he felt in that third session as being due to how open he had become to the drug after the two earlier sessions. And Bogenschutz indicated Mavis' experience is a good example of how effective this general therapeutic protocol can be even in the absence of psychedelic drugs.

However, it was unclear why a subject from the placebo group was presented to the media as a success story from the trial. Is this to suggest the "psychedelic" in psychedelic-psychotherapy is partly placebo? Or is the psychotherapy generating the significant clinical benefits from this novel kind of treatment, and why there was little transparency over the detail that this participant was indeed from the placebo group?

Patient biographies from seven participants in the trial were offered to the media and Mavis’ details did not indicate he was in the placebo group. Instead his biographic details recounted how meaningful the insights he gained were during his sessions in the trial.

“During his first session in January 2019, he recalls negotiating with himself over when he would drink again and why,” the NYU bio on Mavis read. “This led to a sudden epiphany in which he realized that 'drinking equals death. Boom. As though someone flipped a switch, I knew I was done with drinks for good.'”

The researchers clarify they have no direct financial stake in this particular work. Bogenschutz said NYU Grossman School of Medicine has filed a provisional patent for this research but stressed the reason behind this is to make sure no commercial, for-profit entity can monopolize the treatment and make it financially inaccessible to many in the future.

All of this does, however, suggest there is a pre-existing belief that this kind of psychedelic treatment works. Charles Marmar, chair of the department of psychiatry at NYU Langone, was frank in expressing this belief during the recent press conference.

“We believe we will be successful over time in reaching FDA approval,” Marmar said. “We, at NYU School of Medicine, and the field generally in psychedelic psychiatry, will achieve our milestones in the next five to 10 years to get FDA approval for psilocybin and other drugs for addiction and psychiatric illness.”

The findings in the new research are undeniably promising, indicating psilocybin could be helpful in treating alcohol use disorder. But in presenting this new study, and underplaying the impact of the placebo problem, the researchers have somewhat revealed a bias that is relatively prevalent in the world of modern psychedelic science. A underlying belief that these drugs work, will be approved soon, and the research currently being conducted is generated to serve and validate that pre-existing belief.

The new study was published in JAMA Psychiatry.

Source: NYU Langone Health

Bob Stuart
"Can you tell if it is any different than the placebo?"
"No, because almost everybody in the test could tell."
Considering how serious a problem alcoholism is,I say treat it with psilocybin ,and then compare the long term results with other non-psychedelic treatments.
Considering that psilocybin mushrooms are non-toxic and nonaddictive, this sort of research and the authorizations they seek should be fast tracked by the FDA.
There are a lot of different kinds of studies where effective blinding just ain't gonna happen. (Anything with serious side effects, surgeries -- even though researchers sometimes do sham surgeries with anesthetic and a surface incision -- various kind of physical therapy and so forth.) The best you can sometimes do is pass the records on to a separate group for evaluation.

I'm really not that worried about a placebo effect here, because the ultimate question is how many people stop/reduce their dangerous drinking behavior, and the precise mechanism of action seems less important. Perhaps the accuracy of self-reporting of alcohol consumption would change depending on whether subjects knew they had taken the active agent in the study, but that's something the researchers should be able to correct for.
Thanks Rich - but you left a few insights on the table so to speak. My take-away is that psychotherapy for people with low introspection skills or high self-denial behaviors can be really impactful. So does this psilocybin study prove that effective change occurs more rapidly when psychotherapy is combined with psychoactive drugs, or that psychotherapy effects change in SPITE of psilocybin administration during a course of psychotherapy. I'm really fascinated by the psychoactive studies that combine psychotherapy and psychoactives because I find the cohorts are not screened well for personal insight and understandings. The studies define the outcome they are looking for and when they have statistically significant results indicating a success - they publish without analyzing how significant their cohort selection impacted the outcome (they are almost always volunteers you know) or compare the success of the research with the psychotherapists successes in practice outside of the research cohort. I'd say Alcoholics who are killing themselves slowly might be motivated to consider life without booze as a long term alternative after psychotherapy as that Mavis guy did before he received his psilocybin dose. He was the one that makes' Bob's comment "almost everybody in the test could tell" rather trite. If Paul Mavis couldn't tell, how many others in the study couldn't tell until the second or third dose? Paul could not tell even after two placebo doses and one psilocybin dose!
Derek Davies
I am curious who chose high dose Benadryl as a placebo for the control group. This drug in high doses elicits an anticholinergic response that can be quite dangerous. Even if there is some correlation between the Psilocybin response and the anticholinergic effects of high dose Benadryl it is not an appropriate choice for placebo. Psilocybin inhibits the physical needs created by alcohol abuse, so in my opinion a treatment plan over the course of 4 weeks would be an appropriate choice for the treatment of alcoholism, bearing in mind no treatment plan is 100% effective. Personally, I would never agree to participate in any controlled study which utilizes pharmaceuticals that in high doses can elicit anticholinergic effects. The risk of seizure here is just too high.
"it was unclear why a subject from the placebo group was presented to the media as a success story from the trial"
"it seems slightly disingenuous to even frame the study as blinded"
So you're telling me that researchers with an agenda will present misinformation to further their cause? Inconceivable! /S
Robert Peyton
Rich, thank you for a nuanced piece on a difficult topic. I tend to think psilocybin therapy is worthwhile, but it won't advance without rigorous testing and journalists like you need to keep on top of it. I saw two other articles about this study, both headlines were essentially, "LOOK HOW AWESOME SHROOMS ARE". Better we have balanced writing than cheerleaders.