Forget carrots. Researchers have determined that one of the most common amino acids has the power to keep retinas thick and healthy. The finding has the potential to fight vision loss and blindness through this newly discovered metabolic pathway.
At the back of your eye, the retina converts the visual information coming in through your cornea into electrical signals that are shuttled to the brain through the optic nerve. There they are interpreted in the visual cortex and translated into objects we can recognize. The retina consists of a series of photoreceptor cells known commonly as rods and cones. Photoreceptors are particularly demanding cells, requiring a lot of energy to function and maintain themselves. When they die off either through age or disease, the retina begins to thin and vision loss and eventual blindness can occur.
Traditionally, researchers have focused on the way in which photoreceptors use glucose for energy, such as the ACOORD Eye Study that looked at how the intense control of glucose and blood pressure could affect retinopathy in those with type 2 diabetes.
But because retinal cells need so much metabolic support, researchers at the University of Michigan decided to see if there were other compounds involved in their health. They turned to the amino acid glutamine, because it is the most abundant amino acid in the blood. Glutamine is naturally synthesized in the body and can also be consumed from all animal protein sources as well as in nuts, grains, beans and vegetables including spinach and cabbage (and yes, there's actually some in carrots, too).
To test glutamine's role in vision health, the researchers used genetically modified mice that lacked the enzyme glutaminase, which converts glutamine into the fellow amino acid and neurotransmitter, glutamate. Sure enough, compared to a control group whose glutaminase was left intact, the test mice saw a rapid thinning of their retinas corresponding to a loss of photoreceptors.
In digging deeper, the researchers determined that reduced glutamate harmed retinal cells in two ways.
First, along with a reduction in the amino acid aspartate, which was also induced by limiting glutaminase, the cells were unable to build the proteins they needed to function correctly. Second, the retinal cells in the test mice experienced extended periods undergoing something known as the integrated stress response, which is a process cells use to maintain homeostasis when placed under various stressors. The integrated stress response has been shown to lead to cell death if it is activated for too long, as was the case in the study. When this stress response was blocked, the retinal thickness was restored.
The researchers are hopeful that their findings will translate to humans.
“We are now focused on understanding which pathways depend on glutamine and whether they can be targeted by drugs or supplements,” said study co-author Thomas Wubben. "Glutamine to glutamate conversion pathways are negatively impacted in models of human retinal disease. It is possible that resetting metabolism can help prevent vision loss and blindness.”
The study has been published in the journal Communications Biology.
Source: Michigan Medicine via EurekAlert
