Biology

Molecular nanosubmarines can target and kill specific cancer cells

Molecular nanosubmarines can t...
These tiny molecules can hunt down and kill specific cancer cells
These tiny molecules can hunt down and kill specific cancer cells
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A sequence of images taken over 10 minutes shows a human prostate cell under attack by motorized molecules – the cell is made permeable by the nanomachines, which drill through its lipid bilayer membranes – the bottom images clearly show bubbling of the membrane as cytoplasm leaks out of the cell
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A sequence of images taken over 10 minutes shows a human prostate cell under attack by motorized molecules – the cell is made permeable by the nanomachines, which drill through its lipid bilayer membranes – the bottom images clearly show bubbling of the membrane as cytoplasm leaks out of the cell
This is a sample schematic of a nanomachine created by researchers
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This is a sample schematic of a nanomachine created by researchers
An artist's impression of these molecular machines
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An artist's impression of these molecular machines
These tiny molecules can hunt down and kill specific cancer cells
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These tiny molecules can hunt down and kill specific cancer cells

In 2015, scientists from Rice University revealed they had created light-driven nanosubmarines. These tiny molecular machines were activated by ultraviolet light and based on earlier work from Nobel laureate Bernard Feringa, whose ground-breaking research won the prize for chemistry in 2016. These single-molecule machines have now been shown to be able to target, and drill into, specific cancer cells, paving the way for a variety of highly targeted future nanomedicine treatments.

These molecular machines consist of 244 atoms with a tail-like propeller that creates propulsion when exposed to UV light. After proving the concept worked back in 2015, the team moved on to exploring whether the molecular motor could penetrate an individual cell.

"We thought it might be possible to attach these nanomachines to the cell membrane and then turn them on to see what happened," explains chemist James Tour.

First the team needed to attach the molecular motor to a component that allowed it to target a specific cell. In these early experiments a peptide was utilized that drove the molecule to attach itself to the membrane of human prostate cancer cells. The molecules were shown to effectively locate and attach to the targeted cells, but not drill into them until specifically triggered by UV light. Once triggered, the motors spun up to two to three million rotations per second to break through the cell membrane and kill the cell within one to three minutes.

An artist's impression of these molecular machines
An artist's impression of these molecular machines

The obvious challenge that needs to be overcome is to develop an activation trigger other than ultraviolet light, which currently limits the molecular motors to being controllable when concentrated at the surface of tissue. Other triggers are currently being investigated, with near infra-red (IR) light looking like the best option to control these motors when delivered deep into a body.

"In this process, the motor will absorb two photons simultaneously and get enough energy to start the rotor," says Gufeng Wang, a chemist on the Rice University team. "Since near IR light has deep penetration depth, we are no longer limited to the surface of the tissue."

There is much work that still needs to be done before these molecular motors become a real, clinical treatment, but there are a variety of exciting outcomes this technology promises. As well as targeting and destroying cancer cells, the molecular motors could be utilized to deliver drugs directly into diseased cells.

As well as working on additional activation mechanisms, the team is embarking on a series of small animal tests to examine the effectiveness of the molecules on living organisms.

"The researchers are already proceeding with experiments in microorganisms and small fish to explore the efficacy in-vivo," says Tour. "The hope is to move this swiftly to rodents to test the efficacy of nanomachines for a wide range of medicinal therapies."

The research was published in the journal Nature and the video below provides a closer look at the team's breakthrough.

Source: Rice University

Rice University nanomachines constructed to deliver drugs, destroy diseased cells

2 comments
michael_dowling
How is this better than existing treatments that combine a antibody (that seeks out the cancer cell) with a lethal payload ( chemotherapy drug)? The nanosubmarine still has to have a way of finding the cancer cell,and the only difference seems to be it mechanically destroys the cancer cell.
BrianK56
The big question is, why does half the population walk around for 50 years without any sign of cancer and then something breaks and cancer develops. We need to find the cause and fix it, not fix the results of the cancer.