Medical

PrintAlive 3D bioprinter creates on-demand skin grafts for burn victims

PrintAlive 3D bioprinter creates on-demand skin grafts for burn victims
The second-generation PrintAlive bioprinter that produces skin grafts for burn victims on demand
The second-generation PrintAlive bioprinter that produces skin grafts for burn victims on demand
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The second-generation PrintAlive bioprinter that produces skin grafts for burn victims on demand
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The second-generation PrintAlive bioprinter that produces skin grafts for burn victims on demand
Computer rendering of a third-generation PrintAlive bioprinter
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Computer rendering of a third-generation PrintAlive bioprinter
Different patterns of the patient's cells are used to make them go further
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Different patterns of the patient's cells are used to make them go further
In flow organization of 3D soft materials
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In flow organization of 3D soft materials
The PrintAlive skin graft application and bioprinting system
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The PrintAlive skin graft application and bioprinting system
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While most are familiar with the potential for 3D printers to pump out plastic odds and ends for around the home, the technology also has far-reaching applications in the medical field. Research is already underway to develop 3D bioprinters able to create things as complex as human organs, and now engineering students in Canada have created a 3D printer that produces skin grafts for burn victims.

Called PrintAlive, the new machine was developed by University of Toronto engineering students Arianna McAllister and Lian Leng, who worked in collaboration with Professor Axel Guenther, Boyang Zhang and Dr. Marc Jeschke, the head of Sunnybrook Hospital's Ross Tilley Burn Centre.

While the traditional treatment for serious burns involves removing healthy skin from another part of the body so it can be grafted onto the affected area, the PrintAlive machine could put an end to such painful harvesting by printing large, continuous layers of tissue – including hair follicles, sweat glands and other human skin complexities – onto a hydrogel. Importantly, the device uses the patient's own cells, thereby eliminating the problem of the tissue being rejected by their immune system.

The PrintAlive skin graft application and bioprinting system
The PrintAlive skin graft application and bioprinting system

Because growing a culture of a patient's skin cells ready for grafting can typically take more than two weeks, the machine prints the patient's cells out in patterns of spots or stripes rather than a continuous sheet, to make them go further. The result is a cell-populated wound dressing that reproduces key features of human skin and can be precisely controlled in terms of thickness, structure and composition.

Having been under development since 2008, the team recently completed a second-generation, pre-commercial prototype that they say is smaller than an average microwave. This makes it portable enough to easily transport, which gives it the potential to one day revolutionize burn care in rural and developing areas around the world.

"Ninety per cent of burns occur in low and middle income countries, with greater mortality and morbidity due to poorly-equipped health care systems and inadequate access to burn care facilities," says Jeschke. "Regenerating skin using a patient’s own stem cells can significantly decrease the risk of death in developing countries."

So far, the 3D-printed skin grafts have been tested on mice, with the team planning to move onto pigs before clinical trials on humans in the next few years. They were recently named the Canadian winners in the 2014 James Dyson Awards, giving them US$3,500 to continue development and putting them in the running for the $60,000 main prize.

The PrintAlive bioprinter is detailed in the video below.

Sources: University of Toronto, James Dyson Award

PrintAlive Bioprinter

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4 comments
4 comments
Brian M
The video is a joke and reflects very badly on the University of Toronto!
Just hope they are more competent with the bio-printer - Did anyone bother to check the video? Background track drowning out the speaker (not that good in the first place) and then tweaking the music track up even further to damage your eardrums!
No excuse for such poor quality video in this day and age!
bobsue1946
I love how universities are still the leaders in development of new medical ideas. Now how does one keep them away from the "patent"grabbers that inflate the cost to the medical systems around the world.
Richard Unger
Can't hear the narrator, properly and the video sound track sucks. This video is not great, come on guys, This is a great idea. Present it properly.
PaulYak
University depts are still the driving force, but most are sponsored at the student/university/govt. levels so IF they do get to us, they are prohibitively expensive in the places it's needed the most. Working class populations, doing risky jobs, fighting wars....