Inflammatory

Impressive research is suggesting bacterial imbalances in the gut microbiome may play a major role in the development of rheumatoid arthritis. The preclinical study found damage to the gut lining directly correlates with joint inflammation and severity.

Scientists have demonstrated how engineered nasal tissue can not only act as structural reinforcement for troublesome joints, but also how its unique properties can counter inflammation in severe osteoarthritis.

Researchers at Washington University have tested an experimental new treatment for rheumatoid arthritis in mice. The team implanted stem cells that have been reprogrammed to secrete anti-inflammatory drugs only when they sense inflammation.

A new article asserts the condition known as long COVID shares similarities with chronic fatigue syndrome. The researchers say a better understanding into this overlap can inform therapeutics in the future for many kinds of post-viral illnesses.

A landmark study has identified a novel genetic variant associated with severe cases of endometriosis. The gene is known to play a role in several inflammatory diseases and the findings direct researchers toward new non-hormonal drug treatments.

Through a series of ingenious mouse experiments researchers have discovered evidence showing inflammation-induced histamine activity can inhibit the release of serotonin in the brain. The findings suggest histamine may play a key role in depression.

The WHO is launching a large-scale global clinical trial testing whether a trio of pre-existing drugs can treat those hospitalized with severe COVID-19. The project serves as the new phase of WHO’s Solidarity project.

New research is offering a thorough look at the lasting impact of COVID-19 on immune system activity. Tracking a variety of biomarkers the research found immune abnormalities persisting at least six months after patients recover from acute disease.

Investigating the relationship between diet, gut bacteria and systemic inflammation, Stanford University researchers found just a few weeks of following a diet rich in fermented foods can improve microbiome diversity and reduce inflammatory biomarkers.

Researchers have engineered standard baking yeast to treat inflammatory bowel disease. The microbe has been modified to secrete an anti-inflammatory molecule in response to signs of gut inflammation and has proven effective in mouse tests.

A new study investigating how a low-calorie diet alters gut microbial populations is reporting unexpected results, finding a strange relationship between extreme caloric restriction and increased levels of a bacteria linked to inflammatory bowel disease.

A detailed investigation into brain tissue from those who died from COVID-19 has found no trace of the SARS-CoV-2 virus, but “profound molecular markers of inflammation” were seen offering clues to explain long COVID symptoms.