Electronics

World's smallest single-chip system can be injected into the body

World's smallest single-chip s...
The world's smallest single-chip system, sits on the tip of a hypodermic needle
The world's smallest single-chip system, sits on the tip of a hypodermic needle
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The world's smallest single-chip system, sits on the tip of a hypodermic needle
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The world's smallest single-chip system, sits on the tip of a hypodermic needle

The continuing miniaturization of electronics is opening up some exciting possibilities when it comes to what we might place in our bodies to monitor and improve our health. Engineers at Columbia University have demonstrated an extreme version of this technology, developing the smallest single-chip system ever created, which could be implanted with a hypodermic needle to measure temperature inside the body, and possibly much more.

From ladybug-sized implants that track oxygen levels in deep body tissues to tiny "neural dust" sensors that monitor nerve signals in real time, scientists are making big steps when it comes to the functionality of tiny electronic devices. The implant developed by the Columbia Engineers breaks new ground as the world's smallest single-chip system, which is a completely functional electronic circuit with a total volume of less than 0.1 mm3.

That makes it as small as a dust mite, and only visible under a microscope. The tiny chip required some outside-the-box thinking to make, particularly when it comes to the way it communicates and is powered.

Where small electronics might feature radio frequency (RF) modules to transmit and receive electromagnetic radio signals, these wavelengths are too large to be used with a device this small. Ultrasound wavelengths, on the other hand, are far smaller at a given frequency, as the speed of sound is far less than the speed of light that the electromagnetic waves travel at. So, the team incorporated a piezoelectric transducer that acts as an "antenna" for wireless powering and communication via ultrasound.

This combines with an onboard low-power temperature sensor to turn the chip into a probe for real-time temperature sensing, enabling it to monitor body temperature and also fluctuations in temperature driven by the therapeutic application of ultrasound. The implant's capabilities were demonstrated in live mice where it was used for ultrasound neurostimulation, and up to seven were implanted into the mice at a time via intramuscular injection with a syringe.

The scientists imagine these types of chips being implanted into the human body, and then wirelessly communicating information on what they measure via ultrasound. In its current form this is limited to body temperature, but other possibilities include blood pressure, glucose levels and respiratory function.

"We wanted to see how far we could push the limits on how small a functioning chip we could make," says the study's leader Ken Shepard. "This is a new idea of 'chip as system' – this is a chip that alone, with nothing else, is a complete functioning electronic system. This should be revolutionary for developing wireless, miniaturized implantable medical devices that can sense different things, be used in clinical applications, and eventually approved for human use."

The research was published in the journal Science Advances.

Update (May 13, 2021): This article originally compared the volume of this chip to the world's smallest computer. This comparison and the volume of the computer were incorrect and has now been removed from the text. We apologize for the error and thanks to the reader who pointed it out to us.

Source: Columbia University

12 comments
12 comments
Spud Murphy
Great, cue the anti-vaxxer nutters, they've now got "proof" of "there's microchips in the vaccine".
Mike_S
Idea for a new businness: A device to find and extract lost/unknown microrobots/implants from human body.
Worzel
''..... and possibly much more.''
You better believe it!
Bruce H. Anderson
It would be nice for hospital stays so that nurses don't have to wake you up to take vital signs.
guzmanchinky
I've been told these chips have enough power to send tracking signals into space!
Bill S.
We all knew this day was coming. I wonder if Fauci is in on this too.
ChairmanLMAO
Normies like Spud will have a hard time defending against total surveillance domination. Besides, he got nothing to hide, so what's the big deal right. Facebook knows he's just a product.
guzmanchinky
I agree with Spud, this anti-vax conspiracy craziness is a big part of the problem, and this will help fuel them. Just that image will be everywhere on their boards of misinformation...
Xcott Craver
Surely it's not only visible under a microscope, if it's a third of a millimeter in diameter. We can perceive millimeter markings on a ruler with the naked eye.
HAL
I calculated the dimensions of a cube of 0.1 cubic mm and it would measure
0.464mm on a side or about 0.18". Eyeballing the syringe photo, I estimate the
needle is 3-4X the diameter of the chip width or approximately 1.6mm wide.
That's the size of a 1/16" drill bit - perhaps good for a horse but not
pleasant for a human! The syringe for the Pfizer vaccine I received was MUCH
smaller than that! All that being said, the killer app for a implantable
device this small is real-time direct blood pressure monitoring.