New drug may keep cancer metastasis under control
Fighting cancer can sometimes feel like a game of Whack-A-Mole – even after a primary tumor is removed the disease can crop up again in other organs. Now, researchers at the Harry Perkins Institute of Medical Research have developed a drug that can prevent cancer from spreading.
Previous research has shown that before tumors start to spread, they secrete substances that prepare new places for them to settle down. One way in which the disease does this is by making blood vessels in the area “leaky,” allowing the cancer to penetrate them easier. And it’s this process that the new drug, created by researchers at the Harry Perkins Institute, prevents.
“While this behavior of cancer was already known, what we have discovered is that we can interfere with this process because of the way this new drug affects blood vessels,” says Ruth Ganss, an author of the study. “We’ve discovered it restores the leaky vessels which results in the cancer cells flowing past and not setting up shop.”
The drug was originally developed to overcome a different but related problem. Some cancers are known to protect themselves from the immune system by building a barrier of blood vessels around themselves. This drug was designed to “normalize” these blood vessels and make the tumor vulnerable again. And in the latest study, the team realized it could help prevent metastasis as well.
The team says that if all goes to plan, this drug could form a key part of cancer treatment. Not only can it help fight cancer directly, but it could be used to keep patients in remission. After a primary tumor is removed, the drug could be administered to stop any remaining loose cancer cells from taking hold again in another part of the body.
“So we now have a drug that not only opens up the primary tumor for increased immunotherapy and greater treatment access, but it prevents metastatic spreading and if the cancer has already spread, then the drug escalates the patient’s immune response to the new cancer,” says Ganss. “We now know we can interfere early and late in a cancer’s journey.”
This new research adds new pieces to the puzzle of cancer metastasis. Other recent studies have uncovered molecules that can be switched off to slow the process, proteins that protect traveling cancer cells, signaling pathways that control whether a tumor can spread or not, and drugs that can keep mobile cancer cells in a dormant state.
The new research was published in the journal Nature Immunology.