Biology

Plant-animal hybrid cells make solar-powered tissues, organs or meat

Plant-animal hybrid cells make solar-powered tissues, organs or meat
Fluorescent microscope image of the animal cells with embedded chloroplasts (magenta)
Fluorescent microscope image of the animal cells with embedded chloroplasts (magenta)
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Fluorescent microscope image of the animal cells with embedded chloroplasts (magenta)
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Fluorescent microscope image of the animal cells with embedded chloroplasts (magenta)

Scientists in Japan have created hybrid plant-animal cells, essentially making animal cells that can gain energy from sunlight like plants. The breakthrough could have major benefits for growing organs and tissues for transplant, or lab-grown meat.

Animal and plant cells have different energy-producing structures inside them. For animals, that’s mitochondria, which convert chemical energy from food into a form that our cells can use. Plants and algae, meanwhile, use chloroplasts, which perform photosynthesis to generate energy from sunlight to power their cells.

In a new study led by the University of Tokyo, the team inserted chloroplasts into animal cells, and found that they continued to perform photosynthetic functions for at least two days. The chloroplasts were sourced from red algae, while the animal cells were cultured from hamsters.

Previous studies had found success in transplanting chloroplasts into yeast, granting them the new ability of photosynthesis. But that’s a fungus – doing so in animals is next-level.

The team essentially cultivated hamster cells and isolated chloroplasts together for two days, then checked that the animal cells had taken them up by looking for signs of chlorophyll. This compound performs a key role in chloroplasts but shouldn’t normally be present in animal cells, so its presence is a good indicator that the method worked. Conveniently, it naturally fluoresces under certain wavelengths of light.

When the team shone a specific type of laser light on the cells, they quickly saw chlorophyll – and by extension, chloroplasts – inside the hamster cells. Using another technique called pulse amplitude modulation fluorometry, they confirmed that the chloroplasts were still performing photosynthesis.

“As far as we know, this is the first reported detection of photosynthetic electron transport in chloroplasts implanted in animal cells,” said Professor Sachihiro Matsunaga, corresponding author of the study. “We thought that the chloroplasts would be digested by the animal cells within hours after being introduced. However, what we found was that they continued to function for up to two days, and that the electron transport of photosynthetic activity occurred.”

Intriguingly, the team also noticed that the hamster cells grew faster than usual while they were cultured alongside chloroplasts. This suggests that they’re providing a new carbon source, and could hint at a new potential use for these hybrid cells.

“We believe this work will be useful for cellular-tissue engineering,” said Matsunaga. “Lab-grown tissues, such as artificial organs, artificial meat and skin sheets, are made of multiple layers of cells. However, there is a problem that they cannot increase in size due to hypoxia (low oxygen levels) inside the tissue, which prevents cell division. By mixing in chloroplast-implanted cells, oxygen could be supplied to the cells through photosynthesis, by light irradiation, thereby improving the conditions inside the tissue to enable growth.”

The research was published in the journal Proceedings of the Japan Academy, Series B.

Source: University of Tokyo

3 comments
3 comments
TechGazer
Sounds like it has potential. Maybe a future step is to splice chloroplast generating genes into animal cells. There must be lots of useful combinations that evolution didn't try. Photosynthesis might not be all that useful for large animals, but it's different for cultured cells grown in thin layers.
QuantumEngineer
What does this sound like the premise for a B grade Japanese monster movie? What happens when these Frankenstein organisms escape the lab? Evolution follows a path and if nature didn't go there perhaps we should be wise enough to stay off that path. People don't want to eat GMO corn or soybeans, do you think people will want this unnatural creation?
TechGazer
I made a mistake. Animal cells don't generate mitochondria, and plants don't generate chloroplasts; these are organelles that inhabit those cells, so there aren't genes to be spliced in to create them. What they might be able to do is splice in genes that _support_ chloroplasts in animal cells.

Evolution doesn't decide on which paths to take or avoid; it's all local factors that decide whether an organism survives and reproduces. Some paths dead-end, or make it difficult for some mutations to occur or survive. There are probably plenty of possible life forms or biological mechanisms that might be effective or superior, but which simply didn't occur or survive (bad luck in being stepped on by a dinosaur that didn't even see you).

If the result tasted good, was nutritious and safe and cheaper than regular meat, I'd eat it. I don't avoid GMO foods either.