Researchers at MIT have used two experimental cancer drugs in tandem to fight melanomas. The team paired protein kinase inhibitors with ribonuclease drugs and set them loose onto tumors, and found that the combination worked better than either drug does alone. The discovery could help reduce side effects of cancer treatments and make them more effective.
Ribonuclease drugs have been in development for decades as a potential weapon against cancer. These enzymes are naturally produced by all human cells, and their job is to clear out unneeded cellular RNA or that of invading viruses. Harnessing that process and aiming it towards cancer cells has formed the basis of ribonuclease drugs, which are currently in phase 1 clinical trials and reportedly have a success rate of about 20 percent.
Another type of cancer treatment is a class of drugs known as protein kinase inhibitors. Protein kinases are enzymes that perform vital functions in cells, but cancer cells can overexpress them to help them survive. As the name suggests, protein kinase inhibitors bind to those enzymes and block their function, which can help slow the spread of cancer.
While both methods seem promising in their own right, they aren't without their issues. Ribonuclease drugs can also harm healthy cells, and tumors can eventually develop resistance to protein kinase inhibitors. But the MIT team unexpectedly discovered a link between the two that helps them cover each other's weaknesses.
Essentially, cells use kinase proteins to protect themselves from destructive ribonucleases. So, using a kinase inhibitor stops cancer cells from defending themselves, giving the ribonuclease a better chance to get in there and destroy the tumor's RNA.
The team tested the drug combo on human melanoma cells, and found that it was much deadlier to the cancer than usual, and at lower concentrations. If the treatment eventuates to human use, that should reduce the side effects, and cut the chances of the tumors developing resistance to the drugs.
The researchers say the next step is to test the technique in mice, before eventual human clinical trials can be conducted.
The research was published in the journal Molecular Cancer Therapeutics.
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